Objective:To investigate the clinical characteristics, diagnosis, and treatment of primary pancreatic lymphoma (PPL). Methods:Clinical data of six PPL cases diagnosed and treated in the Tianjin Medical University Cancer Hospital were retrospectively analyzed. Results:In all cases, the primary clinical manifestations were abdominal pain, jaundice, and weight loss. The tumor marker level, including CA19-9, of all the cases was within the normal range, with five of the cases misdiagnosed as pancreatic cancer and one misdiagnosed as stomach cancer. In three cases, the pancreatic mass was located at the head of the pancreas, whereas in the other three, the mass was located at the body or tail. Pancreaticoduodenectomy was conducted in one case, laparotomy and biopsy in three cases, and B ultrasound-guided biopsy in the other two cases. All cases were diagnosed as PLL (B cell type non-Hodgkin's lymphoma). Ex-cept for one patient who left the hospital after surgery, the other five underwent chemotherapy. In addition to the death in one case be-cause of postoperative gastrointestinal bleeding, the survival times were 133, 73, 35, 12, and 10 months in the remaining cases. Conclu-sion:PPL is extremely rare in clinical practice, and the treatment methods and prognosis for the disease significantly differ from those for pancreatic cancer. PPL is easily misdiagnosed in clinical practice, which results in unnecessary treatment measures.%目的：探讨原发性胰腺淋巴瘤的临床特点及诊疗方法。方法：回顾分析天津医科大学肿瘤医院1974年10月至2011年3月原发性胰腺淋巴瘤患者6例的临床资料，并结合文献进行讨论。结果：本组6例患者临床症状以上腹部不适、腹部包块、体重减轻、黄疸为主。术前CA19-9均正常，其中5例初步诊断为胰腺占位，1例初步诊断为胃占位；肿瘤位于胰头3例，胰体尾3例；1例行胰十二指肠切除术，3例行开腹探查加肿物切检术，2例行B超引导下穿刺活检术，术后病理证实均为原发性胰腺淋巴瘤（B细胞型和滤泡型非霍奇金淋巴瘤）；除1例自动出院外，其余5例术后接受了不同方案的化疗；除1例术后5天死亡外，其余生存期分别为133、73、35、12、10个月。结论：原发性胰腺淋巴瘤在临床上较为罕见，其治疗方法及预后与胰腺癌有较大不同，在临床上极易造成误诊而采取不必要的治疗措施，临床上应予以重视。
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