小儿肠外营养相关胆汁淤积机制的研究进展

摘要

Parenteral nutrition associated cholestasis (PNAC) mainly occurs in children. Currently identified risk factors include premature infants, lack of enteral feeding, repeated infections, and toxicity or nutrient deficiency of parenteral nutrition solution. Recent studies have shown that nuclear receptor-mediated bile acid transporter may be the key site of PNAC pathogenesis, in which some cytokines play important roles. New anti-cholestatic therapy based on the regulation of expression of these molecules may prevent end-stage liver disease caused by PNAC.%肠外营养相关胆汁淤积(PNAC)主要是儿科疾病,目前已明确的PNAC高危因素包括:早产儿、缺乏肠道喂养、反复感染以及肠外营养液中存在毒性物质或缺乏某些物质.近年发现,细胞核受体介导的胆汁酸转运体可能是PNAC发生的关键位点,而一些细胞因子在其中起重要作用.研究调控上述分子表达的方法,发现新的抗胆汁淤积疗法,可以防止PNAC引起的终末期肝病.