目的 探讨肠内营养(EN)对活动期溃疡性结肠炎患者肠道通透性的影响。方法 采用随机数字表法将24例轻、中度活动期溃疡性结肠炎患者分为常规组(n=11)和常规+ EN组(n=13)，分别给予美沙拉秦+少渣饮食治疗和美沙拉秦+短肽型肠内营养剂治疗14 d。采用高压液相色谱分析法分别检测治疗前后患者尿液中乳果糖及甘露醇的浓度，计算乳果糖/甘露醇排泄率的比值(L/M)。结果 治疗前常规组和常规+ EN组的L/M分别为0.039±0.025和0.072±0.019,两组的差异无统计学意义(P=0.069)。治疗2周后，常规+EN组的L/M为0.038±0.012，明显低于治疗前(P =0.043)，常规组的L/M为0.032±0.022，与治疗前的差异无统计学意义(P=0.730)。结论 EN可以降低活动期溃疡性结肠炎患者的肠道通透性。%Objective To explore the effects of enteral nutrition (EN) on intestinal permeability in patients with active ulcerative colitis (AUC). Methods Twenty-four A UC patients were randomly divided into two groups:routine treatment group (n =11 ) and routine treatment plus EN group (n =13). Patients in routine treatment group were treated with mesalazine as well as low-residue diet, while patients in routine treatment plus EN group received mesalazine and short peptide EN for 14 days. The ratio of lactulose to mannitol in urine (L/M) before and after treatment was detected by high-performance liquid chromatography. Results The L/M ratio was 0. 039 ± 0. 025 in routine treatment group and 0.072 ± 0.019 in routine treatment plus EN group (P =0.069). After 2 weeks of treatment, the L/M ratio of routine treatment plus EN group (0.038 ± 0.012 ) was significantly lower than the pretreatment level (P =0.043 ), while the L/M ratio of routine treatment group between before and after treatment had no significant difference (0.039 ± 0.025 vs. 0.032 ± 0.022, P =0.730). Conclusion EN can effectively improve the intestinal permeability in AUC patients.
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