原发性高血压患者的动态脉压、脉压指数与脉搏波传导速度的相关性研究

摘要

Objective:The aim of the study was to investigate the relationships among ambulatory pulse pressure (PP),pulse pressure index (PPI)and pulse wave velocity (PWV)in patients with essential hypertension(EH).Methods:A total of 198 consecutive patients with EH,who were recruited from January 2013 to December 2013 ,underwent 24-hour ambulatory blood pressure monitoring and PWV.According to the measurements,24-hour mean systolic blood pressure (24 h SBP)and 24-hour mean diastolic blood pressure (24 h DBP),PP and PWV were calculated.Results:The 198 cases were divided into 4 groups,in which PWV<20% predictive value,20% predictive value≤PWV<30% predictive value,30% predictive value≤PWV<50%predictive value and PWV≥50% predictive value.The ambulatory PP and PPI were significantly different among the 4 groups (P <0.05).As the degree of arteriosclerosis increased,the PP and PPI increased.Conclusions:Ambulatory pulse pressure (PP)and pulse pressure index (PPI)can reflect the situation of arteriosclerosis in patients with EH.The ambulatory PP and PPI obtained by ambulatory blood pressure monitoring has more practical significance in guiding the clinical treatment of hyper-tension.%目的：探讨原发性高血压（essential hypertension，EH）患者动态脉压（pulse pressure，PP）、脉压指数（pulse pressure in-dex，PPI）与脉搏波传导速度（pulse wave velocity，PWV）的关系。方法：对2013年1月—12月入选的198例原发性高血压患者进行24 h 动态血压、PWV 检测。测量并计算24 h 收缩压（24 h SBP）、24 h 舒张压（24 h DBP）、PP 及 PWV。结果：根据PWV，将198例患者分为：动脉僵硬度正常组（PWV＜20％预测值）、轻度动脉硬化组（20％预测值≤PWV＜30％预测值）、中度动脉硬化组（30％预测值≤PWV＜50％预测值）及重度动脉硬化组（PWV≥50％预测值）。4组患者的 PP、PPI 有明显差异（P ＜0．05）；随着动脉硬化程度加重，动态脉压（PP）、脉压指数（PPI）增大。结论：PP、PPI 可反映原发性高血压患者的动脉硬化情况。动态血压检测获得的 PP、PPI 对于临床高血压治疗有重要的指导意义。