高龄冠心病患者血清脑利钠肽、左室射血分数与心功能分级的相关性研究

摘要

Objective To investigate the relationship between serum brain natriuretic peptide (BNP) ,left ventricular ejection fraction (LVEF) and cardiac function in more than 80-year-old patients with coronary heart disease. Methods Serum BNP, LVEF and each cardiac functional class in 222 patients were analyzed with variance a-nalysis method. Correlation analysis was carried out at the same time. Results The cardiac functional class was positively correlated with the serum BNP. The serum BNP levels had a statistically significant differences in patients with different cardiac functional class. The cardiac functional class was negatively correlated with the LVEF. The LVEF had a statistically significant difference in patients with different cardiac functional class. Conclusion The serum BNP and LVEF correlate with cardiac functional class, but neither of them may be a unique diagnosis standard of cardiac functional class.%目的 研究脑利钠肽、左室射血分数与80岁以上高龄冠心病患者心功能的关系.方法 方差分析222例患者各心功能分级之间脑利钠肽、左室射血分数的差异,并行相关分析.结果 ①心功能分级与脑利钠肽正相关,不同心功能分级患者脑利钠肽差异有统计学意义(r =0.512,P＜0.05)；②心功能分级与左室射血分数负相关,不同心功能分级患者左室射血分数差异有统计学意义(r=-0.555,P＜0.05).结论 脑利钠肽、左室射血分数与心功能分级有相关关系,但均不能作为诊断心功能分级的唯一标准.