尿肾损伤分子-1在急性肾损伤诊断中的价值

摘要

Objective To explore the diagnostic value of urinary Kidney injury molecule-1 (Kim-1)detec-tion in patients with acute kidney injury (AKI).Method Seventy-one patients with AKI were selected as the study group (AKI group),and 30 healthy individuals were enrolled as the control group.The levels of urinary Kim-1 and serum creatinine (Scr)were measured respectively.Results The urinary Kim-1 and Scr were increased significantly (P <0.01)in AKI group when compared with the control group.The urinary Kim-1 and Scr increased significantly (P <0.01)in AKI stage 1,2 and 3 in AKI group when compared with control group.The urinary Kim-1 and Scr were increased significantly (P <0.01)in AKI stage 2 and 3 when compared with stage 1.The urinary Kim-1 and Scr were increased significantly (P <0.01)in AKI stage 3 when compared with AKI stage 2.There was significant relationship between the urinary Kim-1 and Scr.The area under the receiver operating characteristics curve in the uri-nary Kim-1 was 0.915.Conclusion The urinary Kim-1 excretion increases significantly in AKI group.It maybe has diagnostic value in AKI and used as a sensitive target diagnostic criteria for AKI.%目的探讨尿肾损伤分子1（Kim-1）检测在急性肾损伤（AKI）诊断中的价值。方法选择确诊的AKI患者71例作为AKI组，并选择同时期健康体检者30例为健康对照组，分别检测尿Kim1及血肌酐（Scr）水平。结果AKI组Scr、尿Kim1较健康对照组明显升高（P＜0．01），与健康对照组比较，Scr、尿Kim1在AKI1期、2期、3期均明显升高（P＜0．01），与AKI1期比较，Scr、尿Kim1在AKI2期、3期均明显升高（P＜0．01），与AKI2期比较，Scr及尿Kim-1在AKI3期均明显升高（P＜0．01）；尿Kim1与Scr之间具有明显相关性（r＝0．842，P＜0．01）；尿Kim1ROC曲线下面积为0．915。结论尿Kim1在AKI患者中排泄升高，对AKI具有诊断价值，可能为诊断AKI的敏感指标。