Effects of Simvastatin on Renal Interstitial Fibrosis after Unilateral Ureteral Obstruction in Rats

摘要

THE SEVERITY OF TUBULOINTERSTITIAL FI-BROSIS has long been considered a crucial deter-minant in progressive renal injury and in long-termprognosis in both human and experimentalglomerulonephritis.1 Finding a method to impedeinterstitial fibrosis and limit the progression ofchronic renal diseases towards end-stage renaldisease (ESRD) is an emerging focus in this field.Simvastatin is a new 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor. Re-cent observations have suggested that HMG-CoAredu...