涂层技术在毛细管电泳手性分离中的应用

摘要

手性是自然界的本质属性之一。手性分离分析技术对生命科学、环境科学、生物工程和药物工程等许多学科都具有十分重要的意义。当前，对不同种类手性化合物进行拆分已成为毛细管电泳技术最具特色的研究和应用领域之一。然而，被分析物（或拆分剂）在毛细管内壁的吸附是毛细管电泳手性分离中的常见问题。涂层技术就是采用不同的方法对毛细管内壁进行改性，是抑制非特异性吸附、提高分离效率及分离重现性最简便和最有效的方法。本文主要综述了近十几年来各种涂层技术在毛细管电泳手性分离领域的应用现状，并对毛细管涂层技术今后的发展进行了展望。%Chirality is one of the intrinsic attributes of the nature. Chiral separation and analysis are of great importance in many research fields, such as life science, environmental science, biological engineering and pharmaceutical engineering. Currently, chiral capillary electrophore⁃sis technique used for the enantioselective resolution of different kinds of racemates has become one of the most distinctive research and application fields. However, the adsorption of the analytes ( or chiral selectors) on the inner wall of the capillary is a common problem in cap⁃illary electrophoresis chiral separation. Coating technology, namely modification of the inner wall of the capillary, is the simplest and most effective way to suppress disadvantageous adsorption, and to improve the separation efficiency and analysis repeatability. In this review, the recent applications of different coating procedures in chiral analysis are presented, and the future developments in this field are also prospected.