急诊介入治疗对急性心肌梗死患者血清VEGF、Fg及hsCRP的影响

摘要

Objective: To observe the influence of emergency percutaneous coronary intervention (PCI) on serum levels of vascular endothelial growth factor (VEGF), fibrinogen (Fg) and high sensitive C- reactive protein (hsCRP) in patients with acute myocardial infarction (AMI). Methods: Enzyme linked immunosorbent assay (ELISA) was used to measure serum concentrations of VEGF, Fg and hsCRP in 60 AMI patients undergoing emergency PCI before and after PCI. Results: Compared with before treatment, there were significant decrease in VEGF level [ (134. 5 ± 30.1) pg/ml vs. (101. 5 ± 25. 4) pg/ml], and significant increase in levels of Fg [ (4. 76 ± 0. 24) mg/L vs. (5. 40 ± 0. 26)] mg/L] and hsCRP [ (2. 93 ± 0. 38) mg/L vs. (5. 06 ± 0. 60) mg/L] in AMI patients after emergency PCI, P<0. 05 all. Conclusion: Levels of vascular endothelial growth factor, fibrinogen and high sensitive C- reactive protein are related with AMI and PCI. Combined detection of above indexes may possess important value in e-valuation of severity and judgment of prognosis of AMI patients after PCI.%目的:探讨急诊介入治疗对急性心肌梗死(AMI)患者血管内皮生长因子(VEGF)、纤维蛋白原(Fg)及超敏C-反应蛋白(hsCRP)的影响.方法:采用酶联免疫吸附法(ELISA)检测60例行急诊经皮冠状动脉介入(PCI)治疗的AMI患者术前及术后血清VEGF、Fg及hsCRP的含量.结果:与治疗前相比,AMI患者急诊介入治疗后VEGF[(134.5±30.1) pg/ml比(101.5±25.4) pg/ml]水平明显降低(P＜0.05)、Fg[(4.76±0.24)mg/L比(5.40±0.26)] mg/L]及hsCRP[(2.93±0.38) mg/L比(5.06±0.60) mg/L]水平明显升高(P均＜0.05).结论:血管内皮生长因子、超敏C-反应蛋白、纤维蛋白原水平与急性心肌梗死PCI相关,对上述指标进行联合检测,对评定AMI患者PCI病情、判断预后可能有重要价值.