尼可地尔对微血管性心绞痛的治疗效果

摘要

Objective:To observe the therapeutic effect of nicorandil on microvascular angina pectoris (MAP) .Meth‐ods:A total of 60 MAP patients were randomly divided into nicorandil group (n=30) and routine treatment group (n=30) ,and they were treated for 12 weeks .Onset times and duration of angina pectoris ,changes of related pa‐rameters of ECG treadmill exercise test before and after treatment ,and total effective rate were compared between two groups .Results:Compared with before treatment ,there were significant reductions in onset times and duration of angina pectoris and maximum depression extent of ST segment (P<0.05 or <0.01) and significant increase in total exercise time (P<0.01) after treatment in both groups ;compared with routine treatment group ,there were significant reductions in onset times of angina pectoris [ (10.3 ± 1.6) times/week vs .(9.6 ± 1.7) times/week] and maximum depression of ST segment [ (0.8 ± 0.3) mm vs .(0.6 ± 0.2) mm] ,and significant increase in total exer‐cise time [(7.8 ± 1.4) min vs .(9.4 ± 1.6) min] and total effective rate (73.3% vs .93.3% ) in nicorandil group (P<0.05 or <0.01) .Conclusion:Nicorandil possesses significant therapeutic effect on microvascular angina pectoris , and it is worth further study .%目的：观察尼可地尔对微血管性心绞痛的治疗效果。方法：60例微血管性心绞痛患者被随机分为尼可地尔组（30例）和常规治疗组（30例），治疗12周。观察并比较两组患者治疗前后心绞痛发作次数及持续时间、心电图平板运动试验相关参数的变化情况，并比较两组患者治疗的总有效率。结果：与治疗前比较，治疗后两组患者心绞痛发作次数、持续时间、ST段最大压低幅度均明显减少（ P＜0.05或＜0.01），运动总时间明显延长（ P＜0.01）；且与常规治疗组比较，尼可地尔组心绞痛发作次数[（10.3±1.6）次／周比（9.6±1.7）次／周]、ST段最大压低幅度[（0.8±0.3） mm比（0.6±0.2） mm]减少更显著，总运动时间[（7.8±1.4） min比（9.4±1.6） min]明显延长；尼可地尔组总有效率明显升高（73.3％比93.3％）（ P＜0.05或＜0.01）。结论：尼可地尔治疗微血管性心绞痛效果显著，值得进一步研究。