冠心病合并高脂血症患者血脂水平与主要炎症因子的相关性

摘要

Objective: To study correlation among blood lipids and main inflammatory factors levels in patients with coronary heart disease (CHD) complicated hyperlipidemia.Methods: A total of 130 CHD patients treated in our hospital were selected.According to blood lipid level, they were divided into hyperlipidemia group (n=90) and non-hyperlipidemia group (n=40).Levels of total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), high sensitive C reactive protein (hsCRP), interleukin (IL)-6 and tumor necrosis factor (TNF)-α were measured and compared between two groups.Results: Compared with non-hyperlipidemia group, there were significant rise in levels of hsCRP [(1.52±0.89) mg/L vs.(9.03±1.04) mg/L], IL-6 [(10.52±2.41) mg/L vs.(35.63±3.08) mg/L] and TNF-α [(1.04±0.04) μg/L vs.(10.08±0.25) μg/L] in hyperlipidemia group, P=0.001 all.Pearson correlation analysis indicated that levels of TC, TG and LDL-C were significant positively correlated with levels of hsCRP, IL-6 and TNF-α (r=0.603~0.843, P<0.05 or <0.01), and HDL-C level was significant inversely correlated with levels of hsCRP, IL-6 and TNF-α (r=-0.853~-0.742, P<0.01 all) in hyperlipidemia group.Conclusion: Blood lipid levels are significantly correlated with inflammatory factors levels in patients with coronary heart disease complicated hyperlipidemia.Regulation of blood lipid levels can control inflammatory factors levels, which may have an active effect on prognosis.%目的:研究冠心病合并高脂血症患者血脂水平与主要炎症因子的相关性.方法:选择在我院收治的冠心病患者130例,根据血脂水平分为高脂血症组(90例)和非高脂血症组(40例),检测患者总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白-胆固醇(HDL-C)、低密度脂蛋白-胆固醇(LDL-C)、超敏C反应蛋白(hsCRP)、白介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)水平并进行比较.结果:与非高脂血症组比较,高脂血症组hsCRP[(1.52±0.89) mg/L比(9.03±1.04) mg/L]、IL-6[(10.52±2.41) mg/L比(35.63±3.08) mg/L]和TNF-α[(1.04±0.04) μg/L比(10.08±0.25) μg/L]水平明显升高(P均=0.001);Pearson相关分析显示,高脂血症组TC、TG、LDL-C与hsCRP、IL-6、TNF-α均呈明显正相关(r=0.603~0.843, P<0.05或<0.01),HDL-C与hsCRP、IL-6、TNF-α呈明显负相关关系(r=-0.853~-0.742,P均<0.01).结论:冠心病合并高脂血症患者血脂水平与炎症因子明显相关,调节血脂水平可控制炎症因子水平,对预后可能有积极作用.