北京某医院30~60 岁体检人群体质指数与高尿酸血症的剂量-反应关系

摘要

目的 探究体质指数(BMI)与高尿酸血症(HUA)患病关联强度的剂量-反应关系.方法 选取2012年在北京电力医院就诊的30~60岁的8 866名体检者进行问卷调查.多因素logistic回归模型中引入限制性立方样条探讨BMI与HUA的管理程度及剂量-反应关系分析. 结果 8 866名体检者中,男性5 623名(63. 4% ),女性3 243名(36. 6% );共有1 629例HUA患者(18. 4% ),其中男性患病率为24. 9% (1 399/5 623),女性患病率为7. 1% (230/3 243). HUA组和非HUA组的年龄、性别、吸烟、体质指数、血压、血糖和血脂等均有显著差异(均为P<0. 05).调整年龄、吸烟、收缩压、舒张压、血糖、三酰甘油、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇后,多因素logistic回归结果显示超重男性( OR=1. 68,95% CI:1. 42 ~1. 99)、肥胖男性(OR=2. 16,95% CI:1. 76 ~2. 65)、超重女性(OR=1. 59,95% CI:1. 15~2. 20)和肥胖女性( OR=2. 77,95% CI:1. 79 ~4. 27)均有患HUA的风险(均为P<0. 0001).限制性立方样条分析表明,男性人群中BMI连续变化与HUA的关联强度呈非线性剂量反应关系(χ2 =15. 49, P=0. 0004);女性中呈线性趋势(χ2 =0. 57, P=0. 7521). 结论BMI连续变化与HUA存在一定的关联,其中男性人群为非线性剂量反应关系,女性为线性趋势关系.%Objective To investigate the dose-response relationship between body mass index (BMI) and hyperuricemia (HUA) among aged 30-60 adults in Beijing. Methods A questionnaire survey was conducted on 8 866 adults in Beijing Electric Power Hospital in 2012. Multivariate logistic regression and restricted cubic spline methods were used to explore the relationship between BMI and hyperuricemia management and dose-response analysis. Results Among 8 866 participants, there were 5 623 males (63. 4% ) and 3 243 females (36. 6% ). The prevalence rate of HUA was 18. 4% , and male was higher than female (24. 9% vs. 7. 1% ). Age, sex, smoking, BMI, blood pressure (BP), glucose and serum lipid level were significantly different ( all P <0. 05) . After adjusting for factors such as age, smoking, BP, glucose, total cholesterol, triglyceride, HDL-C and LDL-C, results showed that overweight men ( OR =1. 68, 95% CI: 1. 42-1. 99), obesity men (OR=2. 16, 95% CI: 1. 76-2. 65), overweight women ( OR=1. 59, 95% CI: 1. 15-2. 20) and obesity women (OR=2. 77, 95% CI: 1. 79-4. 27) had increased the risk of HUA (all P<0. 0001). Restricted cubic spline analysis showed a non-linear dose-response relationship between the continuous change in BMI and hyperuricemia in the male population (χ2 =15. 49, P=0. 0004) and a linear relationship in female (χ2 =0. 57, P=0. 7521). Conclusions There is a certain correlation between continuous changes of BMI and HUA. A non-linear relationship is found in male and a linear relationship was found in female.