老年男性患者血清抵抗素与血脂水平的相关性研究

摘要

目的 观察老年男性患者血清抵抗素与血脂水平的关系.方法 选择老年(≥80岁)男性患者220例,根据血脂水平分为血脂异常组(80例)和血脂正常组(140例),使用酶联免疫法测定空腹血清抵抗素浓度,并分析两者关联.结果 血脂异常组患者空腹血清抵抗素浓度较血脂正常组高[(7.16±0.77) ng/ml比(6.21 ±0.63) ng/ml,P＜0.05],血清抵抗素浓度与总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇水平呈负相关(γ=-0.231,-0.254,-0.243,均为P＜0.01),与三酰甘油水平呈正相关(y =0.127,P＜0.01),在控制了年龄、病史和相关用药后,高密度脂蛋白胆固醇与抵抗素水平独立相关(P =0.017).结论 老年男性血脂异常患者空腹血清抵抗素浓度升高,可能与脂代谢紊乱有关.%Objective To investigate the correlation between serum resistin and blood lipids in old male patients. Methods A total of 220 male patients over 80 years old were selected and divided into hyperlipidemia group (n =80) and normal lipid group (n = 140) according to their blood lipids level. The serum resistin concentration was measured by ELISA. Results Serum resistin level was significantly higher in hyperlipidemia group than in normal lipid group [ ( 7. 16 ± 0. 77 ) ng/ml vs. ( 6. 21 ± 0. 63 ) ng/ml, P<0.05]. Serum resistin level was negatively correlated with TC, LDL-C, HDL-C (γ = -0.231, -0.254, -0.243, all P<0.0l) , and positively correlated with TG (γ =0. 127, P<0.01). Resistin was independently correlated with HDL-C after controlling the age and medical history ( P = 0.017 ) . Conclusions Serum resistin level is higher in old male patients with hyperlipidemia and may be related to the disorder of blood lipid.