过氧化物酶体增殖物激活受体γ辅激活子1α在心血管疾病分子机制中作用的研究进展

摘要

心肌肥厚、心力衰竭等心血管疾病严重威胁人类健康。近年文献报道过氧化物酶体增殖物激活受体γ辅激活子1α（ PGC－1α）具有多种生物功能，同时对维持心脏正常功能具有重要意义，越来越多的研究证实PGC－1α在心血管疾病的发生发展中发挥重要作用，本文就PGC－1α在心肌肥厚、心力衰竭、糖尿病性心肌病及冠状动脉粥样硬化分子机制中的作用作简要阐述。%Cardiovascular disease ,such as cardiac hypertrophy and heart failure ,is a common public health burden.Studies in recent years indicate that peroxisome proliferator-activated receptor γcoactivator-1α( PGC-1α) has a variety of biological functions and plays an important role in maintenance of cardiac function.More and more data show that PGC-1αhas important roles for the development of cardiovascular disease.Molecular mechanism role of PGC-1αin cardiac hypertrophy,heart failure,diabetic cardiomyopathy and atherosclerosis will be discussed in the paper .