过氧化物酶体增殖物激活受体β在心血管代谢性疾病中的作用

摘要

心血管代谢性疾病患病率及死亡率持续攀升,严重威胁人类健康.过氧化物酶体增殖物激活受体β(PPARβ)及其配体具有抗炎、抗氧化应激及改善糖、脂代谢的作用,即展现出心血管保护及代谢调节的作用.本文就PPARβ及其配体在降低血压、抗动脉粥样硬化、改善内皮功能、逆转心肌细胞肥大、改善胰岛素敏感性以及预防肥胖等方面进行综述,为同行进一步挖掘PPARβ对心血管代谢性疾病的防治价值提供参考.%The prevalence and mortality rate of cardiometabolic diseases continue to rise,which seriously threaten human's health.Peroxisome proliferator activated receptor β (PPARβ) and its ligands has the role of anti-inflammatory,anti-oxidative stress and improving the metabolism of glucose and lipid,that is to show the role of protecting cardiovascular and adjusting metabolism.In this paper,PPARβ and its ligands were reviewed in the aspects of lowering blood pressure,anti-atherosclerosis,improving endothelial function,reversing cardiomyocyte hypertrophy,improving insulin sensitivity and preventing obesity,to provide a reference for colleagues to further dig the prevention and treatment value of PPARβ on cardiovascular disease.