川芎嗪对脑、脊髓损伤的保护作用及其机制研究进展

摘要

川芎嗪药理作用广泛，临床上用于治疗心脑血管疾病、呼吸系统疾病、泌尿系统疾病、肝硬化、肿瘤等。近年来，川芎嗪对脊髓损伤的保护作用相关研究也逐年增多。大量临床试验和动物实验显示，川芎嗪对缺血性脑血管病、脑退行性疾病、癫痫及脊髓损伤等有保护作用，其主要机制包括抑制细胞凋亡和炎症反应、提高机体的抗氧化水平、改善血液流变学、增加神经丝蛋白和神经营养因子表达、调节细胞内外离子平衡。本文查阅了2003年至今的相关文献，对近10年来川芎嗪对脑和脊髓损伤的保护作用及其机制研究进行综述。%Ligustrazine which has extensive pharmacological effects has been clinically used in the treatment of cardiovascular and cerebrovascular diseases,respiratory diseases,urinary diseases,cirrhosis,cancer,etc.Research of protective effects of Ligustrazine on spinal cord injury has recently increased year by year.Numerous clinical trials and animal experiments suggest that Ligustrazine can play a role on ischemic cerebrovascular disease, degenerative brain disease,epilepsy,spinal cord injury and so on,whose main mechanisms include inhibiting of apoptosis and inflammation,enhancing the body’s antioxidant level,improving hemorheology,increasing expression of neurofilament protein and neurotrophic factors,and regulating balance of the ion intracellular and extracellular.Through consulting the relevant literature since 2003,this article reviews the protective roles and mechanisms of Ligustrazine on cerebra and spinal cord injury for the past 10 years.