人参皂苷Rg3联合奥沙利铂和索拉非尼对肝癌细胞凋亡的影响

摘要

Objective To discuss the effect of Ginsenoside-Rg combined with oxaliplatin and sorafenib on hepatic carcinoma cell apoptosis. Method Ginsenoside-Rg, oxaliplatin and sorafenib were divided into single drug group, two drugs group and three drugs group to act on hepatic carcinoma cell. Multiplication, prophase apoptosis, middle and advanced stage apoptosis were observed. Results To combine three drugs could improve hepatic carcinoma cell inhibition ratio, apoptosis ratio, apoptotic index compared to those of two drugs group or single drugs group(P<0.01). Conclusion To combine Ginsenoside-Rg, oxaliplatin and sorafenib can improve hepatic carcinoma cell inhibition ratio.%目的：探讨人参皂苷Rg3联合奥沙利铂和索拉非尼对诱导人肝癌细胞凋亡的影响。方法分别将人参皂甙Rg 3、索拉菲尼、奥沙利铂3种药物分为单药、两药联合、和三药联合作用于人肝癌细胞，观察细胞增殖情况、早期凋亡情况、中晚期凋亡情况。结果3种药物联合对肝癌细胞的抑制率、细胞凋亡率和凋亡指数显著高于单用一种药物以及两种药物联用（P＜0.01）。结论联合人参皂苷Rg 3、奥沙利铂以及索拉菲尼能够显著提高肝癌细胞的凋亡率。