罗格列酮治疗对脓毒症肺损伤患者血清HMGB1、TNF－α及Th1／Th2影响研究

摘要

Objective To investigate the effect of rosiglitazone on serum HMGB1,TNF-αand Th1/Th2 in patients with lung injury induced by sepsis.Methods 60 patients with sepsis lung injury in our hospital from August 2013 to August 2014, were randomly divided into experimental group and control group according to the medication methods, 30 cases in each group, control group was given conventional western medicine treatment, including intensive care, gastrointestinal decompression, fasting water, added blood volume, anti-inflammatory, maintenance of water and electrolyte balance, improve microcirculation, etc.On the basis of control group, experimental group was treated with rosiglitazone, two times per day, two weeks as a course of treatment.Serum HMGB1, TNF-α, Th1/Th2 were detected in 1, 3, 7, 14 days in all patients.ResuIts Compared with control group post-treatment,serum HMGB1,TNF-αand Th1/Th2 ratio were significantly decreased in the experimental group (P<0.05).ConcIusion Rosiglitazone can significantly reduce the levels of serum HMGB1,TNF-αand Th1/Th2.%目的：探讨罗格列酮辅助治疗对脓毒症肺损伤患者血清高迁移率族蛋白－1（high mobility group box1，HMGB1）、TNF－α及Th1／Th2影响研究。方法收集青海省中医院2013年8月～2014年8月收治的60例脓毒症肺损伤患者，按照用药方法随机分为实验组和对照组，各30例。对照组给予常规西医综合对症治疗，包括重症监护、胃肠减压、禁食水、补充血容量、抗炎、维持水和电解质平衡、改善微循环等。实验组在对照组治疗基础上给予患者罗格列酮，2次／天，2周为1个疗程，于1、3、7、14 d对所有患者的血清血清HMGB1、TNF－α及Th1／Th2进行检测。结果治疗后，与对照组相比，实验组患者各指标均显著改善，血清HMGB1水平降低显著（P＜0．05）；血清TNF－α水平降低较为显著（P＜0．05）；血清Th1／Th2比值降低显著（P＜0．05）。结论罗格列酮辅助治疗能够显著降低HMGB1、TNF－α水平及Th1／Th2比值。