氯噻酮与比索洛尔治疗老年高血压的疗效对比研究

摘要

目的：比较氯噻酮和比索洛尔治疗老年高血压患者的疗效。方法选择2013年1月～2013年12月期间在唐山市工人医院住院治疗的老年高血压患者60例，随机分为治疗组和对照组，各30例。治疗组给予氯噻酮片，对照组予以进口比索洛尔片剂。观察记录2组治疗前后临床疗效，血压，空腹血糖、尿酸、血肌酐、尿素氮和不良反应。结果治疗组总有效率（90.00％）显著高于对照组（73.33％），差异有统计学意义（P＜0.05）；与治疗前相比，治疗组治疗后收缩压、舒张压均显著降低，差异有统计学意义（P＜0.05）；对照组治疗后收缩压、舒张压与治疗前差异有统计学意义（P＜0.05）；与对照组相比较，治疗组治疗后收缩压改善情况显著高于对照组（ P＜0.05），而2组舒张压改善情况差异无统计学意义。治疗前后，2组空腹血糖、尿酸、血肌酐、尿素氮的比较均无统计学差异。治疗组与对照组均无明显不良反应。结论氯噻酮治疗老年高血压的疗效好、副作用少，优于比索洛尔。%Objective To compare curative effect of chlorthalidone and bisoprolol in treatment of hypertension in the elderly man.Methods 2013 January to 2013 December in our hospital treatment of 60 elderly patients with hypertension were randomly divided into treatment group and control group, each of 30 cases.Treatment group was treated with chlorthalidone tablet, control group was treated with imported bisoprolol tablets.Observed and recorded the two groups before and after treatment the clinical curative effect, blood pressure, fasting blood glucose, uric acid, creatinine, urea nitrogen and adverse reaction.Results The total effective rate of the treatment group ( 90.00%) was significantly higher than that of the control group (73.33%), the difference was statistically significant (P<0.05); compared with before treatment, the treatment group before and after treatment systolic blood pressure and diastolic blood pressure were significantly decreased, the difference was statistically significant (P<0.05);the control group after treatment systolic blood pressure diastolic blood pressure, there was statistical significance between before and after treatment ( P<0.05 );compared with the control group, the treatment group after treatment systolic blood pressure was significantly better than the control group (P<0.05), while the two group of diastolic blood pressure had no significant difference in improving.The two groups before and after treatment, fasting blood glucose, uric acid, creatinine, urea nitrogen were no statistically significant difference.The treatment group and the control group had no obvious adverse reactions.Conclusion The curative effect of chlorthalidone treatment of hypertension in the elderly with good curative effect, few side effects, and beffer than bisoprolol.