Chlorthalidone Versus Hydrochlorothiazide for the Treatment of Hypertension in Older Adults

摘要

Background: Some evidence suggests that chlorthalidone may be superior to hydrochlorothiazide for the treatment of hypertension. Objective: To compare the effectiveness and safety of chlorthalidone and hydrochlorothiazide in older adults. Design: Propensity score-matched observational cohort study with up to 5 years of follow-up. Setting: Ontario, Canada. Patients: All individuals aged 66 years or older who were newly treated with chlorthalidone or hydrochlorothiazide and were not hospitalized for heart failure, stroke, or myocardial infarction in the prior year were eligible for inclusion. Each chlorthalidone recipient was matched to up to 2 hydrochlorothiazide recipients on the basis of age, sex, year of treatment initiation, and propensity score.