孟鲁司特钠咀嚼片对过敏性哮喘患儿肺功能的影响

摘要

目的：探讨孟鲁司特钠咀嚼片对过敏性哮喘患儿肺功能的影响。方法选取宝鸡市金台医院儿科过敏性哮喘患儿86例，随机分为2组，对照组43例，予临床常规治疗；实验组43例，在与对照组相同的临床常规治疗基础上加用孟鲁司特钠咀嚼片治疗。观察2组患者治疗前后血清T淋巴亚群、IL-4、IL-6、TNF-α浓度水平，以及FVC、FEV1、PEF水平变化和临床疗效。结果与治疗前比较，2组患者血清CD4＋、CD4＋／CD8＋、FVC、FEV1、PEF水平均升高，血清CD8＋、IL-4、IL-6、TNF-α水平均降低；与对照组比较，实验组患者治疗后血清CD4＋、CD4＋／CD8＋、FVC、FEV1、PEF水平和治疗有效率均高于对照组，血清CD8＋、IL-4、IL-6、TNF-α水平和治疗无效率均低于对照组，以上结果差异均有统计学意义（ P＜0.05）。结论孟鲁司特钠咀嚼片能有效改善过敏性哮喘患儿免疫功能失衡，提高肺功能，且具有较好的临床疗效。%Objective To investigate the effect of montelukast sodium chewable tablets on pulmonary function in children with allergic asthma . Methods 86 cases of children with allergic asthma were randomLy divided into 2 groups, 43 cases in the control group were treated with routine clinical treatment, 43 cases in the experiment group received more with montelukast sodium chewable tablets.Serum T lymphocyte subsets, IL-6, TNF-α, IL-4 concentration levels, as well as FVC, FEV1, PEF levels and clinical efficacy were compared of two groups pre-and post-treatment.Results Compared with pre-treatment, Serum CD4 +, CD4 +/CD8 +, FVC, FEV1 and PEF levels in 2 groups increased, serum CD8 +, IL-4, IL-6, TNF-a levels decreased, compared with the control group, serum CD4 +, CD4 +/CD8 +, FVC, FEV1, PEF level and the effective rate in the experiment group post-treatment were higher, serum CD8 +, IL-4, IL-6, TNF-αlevels and the ineffective rate were lower, the differences were statistically significant (P<0.05).Conclusion Montelukast sodium chewable tablets can effectively improve the imbalance of immune function in children with allergic asthma , improve lung function, and has good clinical efficacy.