利奈唑胺对耐甲氧西林葡萄球菌感染患者降钙素原水平的影响

摘要

目的：探讨利奈唑胺对耐甲氧西林葡萄球菌（ methicillin resistant staphylococcus ， MRS ）感染患者降钙素原（ procalcitonin ，PCT）水平影响。方法选择在上海市第五人民医院急诊科入院治疗的85例对MRS感染患者进行分组作对照研究，对照组42例患者予万古霉素进行治疗，研究组43例患者予利奈唑胺治疗，2w为1个疗程。对比分析2组患者的治疗效果，探究利奈唑胺抗生素对MRS感染患者PCT水平影响。结果2组退热时间、细菌清除时间、细菌清除率及48h病死率比较差异无统计学意义。研究组ICU治疗时间显著短于对照组，差异有统计学意义（ P＜0．05）。2组总有效率比较差异无统计学意义。治疗后，研究组PCT及C－反应蛋白（C－reactive protein，CRP）水平显著低于对照组，差异有统计学意义（P＜0．05）。结论利奈唑胺对MRS感染患者血清降钙素原水平有显著降低的作用，具有较好的临床治疗效果。%Objective To investigate the effect of linezolid on procalcitonin ( PCT) in the treatment of methicillin resistant staphylococcus ( MRS) infection.Methods 85 cases with MRS infection in our hospital were grouped, control group received vancomycin treatment, study group received linezolid, 2 weeks for 1 courses.Clinical effect were compared to explore the linezolid effect of PCT levels in patients with MRS infection.Results After treatment, defervescence time, bacterial clearance time, bacterial clearance rate and 48 hour mortality rate between two groups of patients had no significant difference.Compared with the control group, ICU treatment time in the study group was significantly lower ( P<0.05 ) .There was no significant difference in total effective rate between two groups.After treatment, the PCT and CRP in study group were lower than control group(P<0.05).Conclusion Linezolid has significant function to reduce the serum PCT level of patients with methicillin-resistant staphylococcus infection procalcitonin, which has better clinical curative effect.