养阴清肺颗粒对小儿支原体肺炎合并EB病毒患儿免疫功能的影响

摘要

目的：探讨养阴清肺颗粒对小儿支原体肺炎合并Epstein－Barr（ EB）病毒患儿免疫功能的影响。方法选取湖州市中心医院儿科诊断及治疗的肺炎支原体合并EB病毒感染肺炎患儿108例，按随机数字表法分组，对照组54例予单纯西医治疗，研究组54例在西医治疗基础上予养阴清肺颗粒治疗，检测并记录2组间临床症状改善状况，炎症指标及T淋巴细胞亚群水平，同时对比临床疗效及并发症。结果对照组治疗有效率75．93％低于研究组治疗有效率90．74％（ P＜0．05）；与对照组比较，研究组治疗后退热、咳嗽、湿罗音缓解、肺部X线消失及住院的时间均缩短（P＜0．05），治疗后C反应蛋白（CRP）、白细胞介素6（IL－6）、肿瘤坏死因子α（TNF－α）及白细胞介素8（IL－8）水平降低（P＜0．05），治疗后CD3＋、CD4＋及CD4＋／CD8＋、NK细胞水平升高，CD8＋水平降低（P＜0．05）。结论采用养阴清肺颗粒可以降低肺炎支原体合并EB病毒感染性肺炎患儿炎症因子，提高免疫功能。%Objective To investigate the effect of Yangyinqingfei granula on immune function in the treatment of mycoplasma pneumonia complicated with Epstein-Barr virus of children.Methods 108 mycoplasma pneumonia complicated with Epstein-Barr virus of children from our hospital were selected and randomly divided into two groups.The control group of 54 cases were treated by simple western medicine treatment and the experimental group of 54 cases were treated on the basis of the control group with Yangyinqingfei granula.The improvement of clinical symptoms, inflammation indexes and the levels of T lymphocyte subsets, clinical efficacy and complications were compared.Results The clinical efficacy in experimental group was 90.74%,which was significant higher than that in control group 75.93%(P <0.05).Compared with the control group,the remission duration of fever, cough and rales,the disappearance time of lung X-ray,the length of stay were shorter(P<0.05), the CRP,IL-6,TNF-αand IL-8 levels were lower ( P <0.05 ) , the CD3 +, CD4 +, CD4 +/CD8 + and NK levels were higher, the CD8 +level was lower ( P <0.05 ) . Conclusion Yangyinqingfei granula could reduce the inflammatory factors and improve immune function in the treatment of mycoplasma pneumonia complicated with Epstein Barr virus infection pneumonia in children.