特布他林联合布地奈德雾化吸入治疗慢性支气管炎的疗效观察

摘要

目的 探讨特布他林联合布地奈德雾化吸入治疗慢性支气管炎的临床疗效.方法 选取2015年3月~2016年9月湖州市双林人民医院呼吸内科收治的96例慢性支气管炎患者进行研究,排除相关禁忌后,按照不同的治疗方法分为对照组(n=48)和研究组(n=48);对照组患者给予常规对症支持治疗;研究组在对照组的基础上给予特布他林5 mg联合布地奈德800μg雾化吸入治疗,2次/d,连续治疗14 d.结果 研究组临床总有效率(95.83%)高于对照组(83.33%),组间比较差异有统计学意义(P<0.05);研究组患者咳嗽、喘息、哮鸣音、湿啰音消失时间明显短于对照组,组间比较差异具有统计学意义(P<0.05);研究组患者动脉血二氧化碳分压(PCO2)和动脉血氧分压(PaO2)明显高于对照组,组间比较差异具有统计学意义(P<0.05);研究组患者和对照组患者不良反应发生率分别为6.25%和10.42%,组间比较差异无统计学意义.结论 特布他林联合布地奈德进行雾化吸入治疗可使临床有效率提高,并缩短临床症状消失时间,提高动脉血PCO2和PaO2,缓解患者病痛,提高生活质量.%Objective To study the effect of terbutaline combined with budesonide inhalation in the treatment of chronic bronchitis. Methods 96 patients with chronic bronchitis in department of respiratory medicine of people's Hospital of Huzhou City from March 2015 to September 2016 were selected. After the relevant contraindications were excluded, the patients were divided into control group (n=48) and study group (n=48) according to different treatment methods. The patients in the control group received routine symptomatic supportive treatment, and the patients in the study group was given 5 mg terbutaline and 800 μg budesonide aerosol inhalation on the basis of the control group, with 2 times/d and 14 ds for continuous treatment. Results The total effective rate of the study group (95.83%) was higher than that of the control group (83.33%), the difference between the two groups was statistically significant (P<0.05). The disappearance time of coughing, wheezing, wheezing, rales of patients in the study group were significantly lower than those of the control group, the difference between the two groups was statistically significant (P<0.05). The arterial partial pressure of carbon dioxide (PCO2) and arterial oxygen partial pressure (PaO2) of patients in the study group were significantly higher than those of the control group, the difference between the two groups was statistically significant (P<0.05). The incidence of adverse reactions in the study group and the control group was 6.25% and 10.42% respectively, and there was no significant difference between the two groups. Conclusion The aerosol inhalation of terbutaline combined with budesonide in the treatment of chronic bronchitis can improve the clinical efficiency, shorten the disappearance time of the clinical symptoms, improve the PCO2 and PaO2 of the arterial blood, relieve the pain and improve the quality of life of the patients, and have higher clinical application value.