枸地氯雷他定片联合复方甘草酸苷片治疗慢性荨麻疹临床疗效及安全性比较

摘要

目的 探讨枸地氯雷他定片联合复方甘草酸苷片治疗慢性荨麻疹临床疗效及安全性.方法 选取本院2014年12月～2015年12月收治的慢性荨麻疹患者100例,以随机数字表法分为对照组和观察组,每组50例.对照组给予枸地氯雷他定单用,观察组在此基础上加用复方甘草酸苷片辅助治疗;比较2组患者近期疗效,治疗前后7d荨麻疹活动性评分、实验室指标水平及随访复发率.结果 观察组患者近期治疗总有效率(96.00％)显著高于对照组(76.00％)(P<0.05);治疗后7 d,观察组患者风团和瘙痒评分(0.79±0.20)分、(0.65±0.10)分均显著低于对照组(1.54±0.29)分、(1.29±0.42)分(P<0.05);观察组患者治疗后IL-4、IFN-γ及IgE水平(28.16±4.10)pg/mL,(11.95±3.05)pg/mL,(55.21±11.37)g/L均显著优于对照组(35.40±7.92)pg/mL,(7.23±1.89)pg/mL,(73.75±15.09)g/L(P<0.05);观察组患者随访6个月和12个月复发率(10.00％,18.00％)均显著低于对照组(24.00％,36.00％)(P<0.05).结论 枸地氯雷他定片联合复方甘草酸苷片治疗慢性荨麻疹可有效缓解皮损症状,改善相关实验室指标水平,并有助于避免远期复发.%Objective To investigate the clinical efficacy and safety of triclosan in combination with compound glycyrrhizin in the treatment of chronic urticaria. Methods A total of 100 patients with chronic urticaria who were enrolled in our hospital from December 2014 to December 2015 were divided into control group and observation group by random number table method,with 50 cases in each group. The control group was given desloratadine alone, and the observation group was treated with on the basis of the addition of compound glycyrrhizin tablets adjuvant therapy.compare the two groups of patients withThe short-term efficacy,the scores of 7 days urticaria activity,the laboratory indicators and the rate of follow-up recurrence were compared before and after treatment in two groups. Results The total effective rate (96.00％) of the observation group was significantly higher than that of the control group (76.00％) (P <0.05). After the treatment of 7days, the urticaria and itching score in the observation group [(0.79 ± 0.20), (0.65 ± 0.10)] were significantly lower than the control group [(1.54 ± 0.29), (1.29 ± 0.42)] (P<0.05). The levels of IL-4, IFN-γ and IgE in the observation group [(28.16 ± 4.10) pg / mL, (11.95 ± 3.05) pg / mL, (55.21 ± 11.37 g / L) were significantly higher than those in the control group[(35.40 ± 7.92) pg/mL,(7.23 ± 1.89) pg/mL, (73.75 ± 15.09) g/L] (P<0.05). The recurrence rate (10.00％, 18.00％) in the observation group was significantly lower than that in the control group (24.00％, 36.00％) (P<0.05).Conclusion The treatment of chronic urticaria with cisplatin combined with compound glycyrrhizin can alleviate the symptoms of skin lesions, improve the level of related laboratory indicators and help to avoid long-term recurrence.