Objective To explore the persistent cerebrospinal fluid drainage and intrathecal injection of urokinase in prevention and treatment of cerebral vasospasm after aneurysm surgery.Methods The effect of prevention and treatment of cerebral vasospasm after aneurysm surgery in 40 patients, using the method combined with intrathecal injection of urine kinase for persistent cerebrospinal fluid drainage, and classified as the observation group;the other 40 cases patients with persistent cerebrospinal fluid drainage intervention, and classified as the control group, two groups of patients were in Shandong Provincial Hospital from January 2016 to January 2017.Results The incidence of rebleeding in two groups had no significant difference in observation of cerebral vasospasm in patients with the incidence was significantly lower than the control group, the observation The incidence of cerebral vasospasm group was 15.0%, 37.5% in the control group, compared two groups of patients with the prognosis, the obvious observation group of patients with good prognosis, comparison between groups showed significantly(P<0.05).Conclusion Persistent cerebrospinal fluid drainage and intrathecal injection of urokinase on the clinical study of postoperative cerebral vasospasm aneurysm found the simple, compared with continuous drainage of cerebrospinal fluid, can improve the clinical condition of patients, and promote the recovery of patients, reduce cerebral vascular spasm, so it is worthy of reference.%目的 探究脑脊液持续外引流联合鞘内注入尿激酶防治动脉瘤术后脑血管痉挛的效果.方法 针对40例患者进行动脉瘤术后脑血管痉挛的防治,使用方法为脑脊液持续外引流联合鞘内注入尿激酶,并归为观察组;针对另外40例患者使用脑脊液持续外引流干预,并归为对照组,2组患者均为山东省立医院神经外科2016年1月～2017年1月间收治.结果 2组患者再出血的发生率无明显差异,观察组患者的脑血管痉挛发生率则明显低于对照组,其中观察组脑血管痉挛发生率为15.0%,对照组则为37.5%,比较2组患者预后评价情况,明显可见观察组患者的预后较好,组间比较差异具有统计学意义.结论 脑脊液持续外引流联合鞘内注入尿激酶防治动脉瘤术后脑血管痉挛的临床研究发现,其相比单纯的脑脊液持续外引流而言,能够改善患者临床情况,同时促进患者恢复,减少脑血管痉挛的发生,因此值得临床借鉴.
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