早期梅毒患者采用青霉素联合头孢曲松治疗对TRUST阴转率、血清固定率的影响

摘要

目的 探讨早期梅毒患者采用青霉素联合头孢曲松治疗临床疗效.方法 将2014年2月~2016年2月本院治疗的60例早期梅毒患者纳入本次研究中,按照随机数字表法分为对照组(单纯性采用青霉素治疗)与治疗组(青霉素与头孢曲松钠),各30例.记录2组患者1周内皮损消退情况,分别于治疗后3个月、6个月、9个月、12个月进行甲苯胺红加热血清试验(TRUST),统计2组患者治疗后血清固定率.结果 治疗组患者1周内皮损消退率为90.0%(27/30),明显高于对照组66.7%(20/30),χ2=4.81,P=0.02;治疗组患者治疗后3个月、6个月、9个月、12个月时TRUST转阴率分别为36.7%(11/30)、70.0%(21/30)、86.7%(26/30)、90.0%(27/30),对照组为13.3%(4/30)、26.7%(8/30)、50.0%(15/30)、63.3%(19/30),(χ2=4.35、11.27、9.31、5.96,P=(0.03、0.00、0.00、0.01).治疗组血清固定率为3.3%(1/30),明显低于对照组20.0%(6/30),(χ2=4.04,P=0.04).结论 青霉素联合头孢曲松钠治疗早期梅毒有助于促进患者皮损的消失,加速患者梅毒血清转阴及降低血清固定率,疗效显著,有待进一步研究以推广.%Objective To investigate the clinical efficacy of penicillin combined with ceftriaxone in early syphilis patients.Methods60 patients with early syphilis treated from February 2014 to February 2016 were included in the study,according to the random number table method,the patients were divided into control group (simple penicillin treatment) and treatment group (Penicillin and ceftriaxone sodium), 30 cases in each group.The skin lesions subsided within one week of two groups were recorded.The toluidine red blood serum test (TRUST) was carried out at 3 months, 6 months, 9 months and 12 months after treatment, and the serum fixation rate of the patients in the two groups were observed.ResultsThe rate of pain relief within one week in the treatment group was 90.0% (27/30), which was significantly higher than that in the control group (66.7%, 20/30), (χ2=4.81, P=0.02);TRUST negative rates of the treatment group after treatment for 3 months, 6 months, 9 months and 12 months were 36.7%(11/30), 70.0% (21/30), 86.7% (26/30), 90.0% (27/30),the control group was 13.3%(4/30), 26.7% (8/30), 50.0% (15/30), 63.3% (19/30), [χ2=(4.35,11.27,9.31,5.96), P=(0.00,0.00,0.00, 0.01)].The serum fixation rate in the treatment group was 3.3%(1/30), which was significantly lower than that in the control group (20.0%, 6/30),(χ2=4.04, P=0.04).ConclusionPenicillin combined with ceftriaxone sodium in the treatment of early syphilis patients can help to promote the disappearance of skin lesions, accelerate the patients with syphilis serum negative and reduce serum fixation rate, the effect is significant, to be further studied to promote.