左炔诺孕酮联合达那唑胶囊治疗子宫内膜异位症患者的疗效与安全性

摘要

目的 左炔诺孕酮联合达那唑胶囊治疗子宫内膜异位症患者的疗效与安全性.方法 选取子宫内膜异位症患者90例,采用随机数字表法将患者分为试验组与对照组,各45 例.对照组患者使用达那唑胶囊治疗,试验组在对照组基础上服用左炔诺孕酮治疗,观察治疗前、治疗后1、3 个月试验组与对照组临床疗效及血清CA125、CA199、卵巢功能,不良反应发生率.结果 经3 个月治疗,试验组临床症状评分低于对照组( P< 0.05);血清CA125、CA199水平下降,与对照组同期比较,试验组下降明显( P< 0.05);卵巢功能恢复明显,与对照组同期比较,差异具有统计学意义( P< 0.05).2组不良反应发生率相比,差异无统计学意义.结论 左炔诺孕酮达那唑胶囊治疗子宫内膜异位症患者比单用达那唑胶囊治疗效果更好,安全性更高.%Objective To evaluate the efficacy and safety of levonorgestrel combined with danazol capsules in the treatment of endometriosis patients.Methods Ninety patients with endometriosis were randomLy divided into experimental group and control group(45 cases).The control group was treated with danazol capsules.The experimental group was treated with levonorgestrel on the basis of the control group.The clinical efficacy and serum CA125,CA199,ovarian function,and ovarian function were observed before and one month and three months after treatment.Adverse reaction rate.Results After three months of treatment,the clinical symptoms of the experimental group were lower than the control group(P<0.05); serum CA125,CA199 levels decreased,compared with the control group,the test group decreased significantly(P<0.05); ovarian function recovery Compared with the control group,the difference was statistically significant(P<0.05).two group compared with the incidence of adverse reactions,the difference was not statistically significant.Conclusion Levonorgestrel danazol capsules treatment of endometriosis Bitter patients than the use of danazol capsules better treatment,higher safety,worthy of clinical application to promote.