磷酸铝凝胶联合奥美拉唑治疗消化性溃疡的临床效果

摘要

Objective To study curative efficacy of aluminum phosphate gel combined with omeprazole in treatment of peptic ulcer and its effects on Gas, TGF-αlevels.Methods 80 patients of peptic ulcer who received therapy from April 2015 to April 2016 in our hospital were selected as research objects.According to random number table, those patients were divided into the observation group and the control group, 49 patients in each group.the control group was treated with omeprazole, while the observation group was treated with aluminum phosphate gel combined on the basis of control group.Then Transforming growth factor, adverse reaction and curative effect were compared.Results After treatment, the serum levels of Gas and TGF-αin both groups were improved (P<0.05); Two weeks after treatment,the level of GAS in the observation group were lower than those in the control group(P<0.05), TGF-αlevel was higher than that in control group(P<0.05); The total incidence of adverse reactions in the observation group was lower than that in the control group(P<0.05); The total effective rate in the observation group was higher than that in the control group(P<0.05). Conclusion Combined use of aluminum phosphate gel and omeprazole in the treatment of peptic ulcer can effectively improve the patient-related serum markers, improve the quality of ulcer healing, significant efficacy, high safety and low incidence of adverse reactions.%目的 探讨磷酸铝凝胶联合奥美拉唑治疗消化性溃疡的临床效果及对血清Gas、TGF-α水平的影响.方法 选取2015年4月~2016年4月余姚市第二人民医院接诊的98例消化性溃疡患者,按随机数表法分为观察组和对照组,各49例.对照组采用奥美拉唑进行治疗,观察组在对照组的基础上联合磷酸铝凝胶进行治疗.比较2组血清胃泌素(gastrin,Gas)、转化生长因子α(transforming growth factor,TGF-α)、不良反应及治疗效果.结果 治疗后,2组患者Gas和TGF-α水平均得到改善(P<0.05);治疗后2 w,观察组患者Gas水平显著低于对照组(P<0.05),TGF-α水平显著高于对照组(P<0.05);观察组患者不良反应总发生率低于对照组(P<0.05);观察组患者总有效率显著高于对照组(P<0.05).结论 磷酸铝凝胶联合奥美拉唑治疗消化性溃疡可有效改善患者病症相关血清指标,提高溃疡愈合质量,疗效显著且安全性高,不良反应发生率低.