扎鲁司特对季节性过敏性哮喘患者炎性因子及免疫功能的影响

摘要

目的 探讨扎鲁司特对季节性过敏性哮喘患者的炎性因子及免疫功能影响.方法 选取浙江省湖州市德清人民医院呼吸科收治的季节性过敏性哮喘患者182例,按随机数字表法分组,各91例.对照组予以布地奈德福莫特罗粉吸入剂治疗,研究组在对照组基础上予以扎鲁司特治疗,检查记录2组间血清炎性因子水平、外周血T淋巴细胞亚群、血清免疫球蛋白水平、肺功能,比较2组患者临床疗效.结果 与对照组比较,研究组治疗后血清TNF-α、IL-4、IL-6水平较低,IL-10水平较高,CD8+T淋巴细胞水平较低,CD3+、CD4+T淋巴细胞、CD4+/CD8+水平较高,血清IgE、IgG、IgA水平较低,PEF、FEV1、FEV1/FVC水平较高,差异均具有统计学意义(P<0.05).研究组治疗有效率为94.51%显著高于对照组81.32%(P<0.05).结论 扎鲁司特能够明显降低季节性过敏性哮喘患者血清炎症因子水平,提高细胞免疫功能,降低免疫球蛋白水平,有效改善肺功能,具有较好的临床疗效.%Objective To investigate the influence of Zafirlukast on the inflammatory factors and immune function of patients with seasonal allergic asthma.Methods 182 patients with seasonal allergic asthma from the department of respiratory in our hospital were selected and divided into two groups, 91 cases in each group.The control group treated with budesonide and formoterol fumarate powder for inhalation, the experiment group received Zafirlukast on the basis of the control group,serum levels of inflammatory cytokines,peripheral blood T lymphocyte subsets,serum immunoglobulin levels, lung function,and the clinical effect were compared after the treatment.Results Compared with the control group, serum levels of TNF-,IL-4,IL-6 were lower, level of IL-10 was higher in the experiment group after treatment, CD8 +T lymphocyte levels was lower, CD3 +, CD4 +T lymphocyte and CD4 +/CD8 +ratio levels were higher after treatment, serum levels of IgE, IgG, IgA were lower after treatment, levels of PEF,FEV1 ,FEV1/FVC were higher after treatment, the difference was statistically significant (P<0.05).The effective rate in the experiment group 94.51% was higher than the control group 81.32% (P<0.05).Conclusion Zafirlukast can significantly reduce the levels of serum inflammatory factors in patients with seasonal allergic asthma, improve the cellular immune function, reduce the level of immunoglobulin, effectively improve lung function, shorten the length of hospital stay, has better clinical curative effect.