加巴喷丁与卡马西平治疗老年原发性三叉神经痛患者的临床疗效观察

摘要

Objective To compare the clinical efficacy of gabapentin and carbamazepine in the treatment of elderly patients with primary trigeminal neuralgia.Methods 96 cases of elderly patients with primary trigeminal from March 2014 to March 2016 were selected and randomly divided into gabapentin group and carbamazepine group, which each group with 48 cases.The clinical efficacy, adverse reactions and changes of pain, insomnia, anxiety, depression status and oxidative stress indexes were compared.Results After treatment, there was no significant difference in total effective rate between two groups.And the excellence rates in gabapentin group was 60.4%, which significantly higher than that in carbamazepine group with 37.5%, the difference was statistically significant ( P <0.05 ) .After treatment, VAS score and sleep disturbance score in gabapentin group were significantly lower than those in carbamazepine group, the difference was statistically significant (P<0.05), and SAS score and SDS score were also significantly lower than those in carbamazepine group, the difference was statistically significant (P<0.05).The adverse reactions rates in gabapentin group was 22.9%, which significantly higher than that in carbamazepine group with 43.8%, the difference was statistically significant ( P <0.05 ) . Conclusion Compared with carbamazepine, gabapentin in the treatment of elderly patients with primary trigeminal neuralgia can enhance clinical effect , improve pain, insomnia, anxiety, depression status.%目的 比较观察加巴喷丁与卡马西平治疗老年原发性三叉神经痛患者的临床疗效.方法 选取2014年3月~2016年3月于天台县中医院住院及门诊治疗的96例老年原发性三叉神经痛患者,随机分为卡马西平组和加巴喷丁组,每组各48例,比较2组的疗效、不良反应发生情况以及疼痛、睡眠、焦虑、抑郁状况变化.结果 治疗后,2组总有效率比较,差异无统计学意义.加巴喷丁组的显效率为60.4%,明显高于卡马西平组的37.5%,差异有统计学意义(P<0.05).加巴喷丁组治疗后视觉模拟评分(VAS)和睡眠干扰评分明显低于同期卡马西平组水平,差异有统计学意义(P<0.05),焦虑自评量表(SAS)评分和抑郁自评量表(SDS)评分亦明显低于同期卡马西平组水平,差异有统计学意义(P<0.05).加巴喷丁组的不良反应发生率为22.9%,明显低于卡马西平组的43.8%,差异有统计学意义(P<0.05).结论 与卡马西平相比,加巴喷丁治疗老年原发性三叉神经痛患者能够明显提高临床治疗效果,改善患者的疼痛、睡眠和焦虑抑郁情绪.