重复经颅磁刺激在酒精成瘾患者诊疗中的应用

摘要

酒精成瘾作为一种慢性高复发性的疾病,严重影响个人健康并导致相关社会问题.但目前对酒精成瘾的治疗仍缺少降低渴求、预防复发的有效方法.重复经颅磁刺激是目前成瘾领域逐渐兴起的一种干预手段,本文综述了其在酒精成瘾领域的相关研究,介绍了经颅磁刺激的工作原理及其对酒精依赖者相关脑区功能及神经递质的影响.已有研究显示重复经颅磁刺激对于降低酒精渴求有一定效果,但现有研究方案及其结果不尽相同,最佳治疗方案有待明确.在今后的研究中,可以尝试探索优化治疗方案,增加生物学疗效指标,为进一步推广临床应用提供更多证据.%Alcohol dependence as a chronic disease with high relapse rates,seriously affects individ-ual health and causes related social problems. However,the treatment of alcohol addiction currently lacks ef-fective interventions to reduce craving and prevent relapse. Repetitive transcranial magnetic stimulation ( rTMS) is an emerging intervention in the field of addiction. This paper reviews the researches to introduce the working principle of TMS and its effects on brain functions and neurotransmitters of alcohol dependent pa-tients. Studies have shown that rTMS has a certain effect on reducing alcohol craving,but the existing re-search protocols and their results are not exactly same,and the best parameters need to be clarified. Future research can try to explore optimized treatment options,and find biological efficacy indicators to provide more evidence for further clinical application.