药物联合分散内观认知疗法对男性偏执型精神分裂症康复期疗效观察

摘要

目的 观察药物联合分散内观认知疗法对男性偏执型精神分裂症康复期患者临床症状的疗效.方法 选取男性偏执型精神分裂症康复期患者100例,分为研究组与对照组,研究组在药物治疗的基础上给予连续28d每天3h的分散内观认知疗法(Discontiguous NaiKan Cognitive Therapy,DNCT)；对照组只给予原有药物治疗；在治疗前,治疗后以及治疗后12周时进行PANSS量表以及NOISE量表评分观察疗效变化.结果 研究组脱落10例,对照组脱落1例,研究组40例患者治疗后PANSS量表总分[(54.00±10.19)分,(45.05±5.28)分,t=5.430,P＜0.01]、阳性症状量表分[(11.00±3.33)分,(9.53±1.85)分,t=3.670,P=0.01],阴性症状量表分[(12.15±4.38)分,(9.40±2.15)分,t=4.371,P＜0.01],一般精神病理量表[(26.90±5.66)分,(22.65±3.07)分,t=4.494,P＜0.01]等评分显著低于治疗前,均差异具有统计学意义.与对照组相比,治疗后研究组PANSS量表总分[(45.05±5.28)分,(52.04±10.36)分,t=-3.876,P＜0.01]、阴性症状量表分(t=-3.789,P＜0.01)、复合量表分(t=2.251,P=0.027]、一般精神病理量表(t=-3.336,P=0.01)等低于对照组,差异均具有统计学意义.12周随访研究组PANSS量表总分(t=4.764,P＜0.01)、阳性症状量表分(t=2.335 P=0.025)、阴性症状量表分(t=3.083,P=0.004)、一般精神病理量表(t=4.325,P＜0.01)评分低于治疗前,差异均具有统计学意义.研究组患者治疗后NOSIE量表病情总估计评分(t=-4.730,P＜0.01)、总积极因素(t=-2.446,P=0.019)评分显著高于治疗前,总消极因素(t=3.083,P=0.004)评分显著低于治疗前,均差异具有统计学意义.与对照组相比,治疗后研究组NOSIE量表总消极因素(t=-3.953,P=0.000)低于对照组,差异具有统计学意义.12周随访研究组NOSIE量表总消极因素(t=2.126,P=0.040)评分仍显著低于治疗前,总积极因素评分(t=-2.054,P=0.047)仍显著高于治疗前,差异均具有统计学意义.结论 药物治疗联合分散内观认知治疗有助于改善康复期偏执型精神分症患者的精神症状,特别是阴性症状,在12周随访时疗效依然存在.%Objective To explore the influence of clinical symptoms and applicability of discontiguous naikan cognitive therapy(DNCT) among convalescent schizophrenic patients.Methods Applying DNCT,100 convalescent paranoid schizophrenic patients with convalescent clinical state were consecutively recruited.All the patients were randomly divided into DNCT group and control group and were pretreated with antipsychotic agent therapy,40 patients in DNCT group and 49 patients in control group entered the statistic analysis,11 lost.In DNCT group,the patients received DNCT for successive 28 days.In control group,the patients only received antipsychotic agent therapy.Positive and Negative Syndrome Scale (PANSS),Nurses'Observation Scale for Inpatient Evaluation (NOSIE) were administered to all subjects pre- and post-treatment.Results After treatment,in the study group,total PANSS scales ( (54.00 ± 10.19 ) vs (45.05 ± 5.28 ),t =5.430,P ＜ 0.01 ),the positive symptom item ((11.00±3.33) vs (9.53 ±1.85),t=3.670,P=0.01),negative symptoms item((12.15 ±4.38) vs (9.40± 2.15 ),t =4.371,P ＜ 0.01 ),general psychopathology item ( (26.90 ± 5.66) vs (22.65 ± 3.07 ) 分,t =4.494,P＜0.01 ) scored lower than before,The difference was statistically significant.PANSS study group after treatment,total scores( (45.05 ±5.28 ) vs (52.04 ± 10.36),t=-3.876 P＜0.01 ),negative symptom item score( t =- 3.789,P ＜ 0.01 ),composite item ( t =2.251,P =0.027 ),the general psychopathology item ( t =- 3.336,P =0.01 ),score significantly lower than the control group.After twelve weeks follow-up study,in the study group,PANSS total scores ( t =4.764,P ＜ 0.01 ),item score of positive symptoms ( t =2.335,P =0.025 ),negative symptoms item score( t =3.083,P =0.004) ),genial psychopathology item score ( t =4.325,P ＜ 0.01 ) was still significantly lower than before treatment,the difference was statistically significant.In study group,after treatment,NOSIE Scale total negative factors scores( t =3.083,P =0.004) were significantly lower than before,total positive factors( t =-2.446,P=0.019),the total estimated factor in the disease scores ( t =-4.730,P ＜ 0.001 )were significantly higher than before treatment.After treatment,in the study group,negative factors ( t =-3.953,P=0.000) were significantly lower than the control group,twelve weeks follow-up,study group total negative factors of NOSIE scale score( t =2.126,P =0.040) was still lower than before treatment,the difference was statistically significant,total positive factor( t =- 2.054,P =0.047 ) still higher than before treatment,the difference was statistically significant.Conclusion DNCT can possibly improve part clinical symptoms of patients with convalescent schizophrenia to a certain extent,especially negative symptom,and the impact remained to the twelve weeks,but need to further prove the effect of naikan cognitive therapy.