红花注射液对急性脑梗死患者神经功能及血清IL-6、IL-10水平的影响

摘要

Objective:To explore the association between serum interleukin-6 (IL-6),interleukin-10 (IL-10) level and nerve function and observe the effect of Safflower injection in acute cerebral infarction (ACI) patients.Methods:97 cases of acute cerebral infarction patients were using enzyme-linked immunosorbent assay (ELISA) for detection of serum IL-6 and IL-10 levels for analyse their correlation and compared with healthy control group.All patients were use "The Envelope Method" divided into the treatment group and control group randomly:the routine therapy group (the patients were given routine therapy) and safflower injection group (the patients were given safflower injection 14 days in addition to the routine Therapy).The neurology functional and the serum levels of IL-6 and IL-10 were investigated in 24 h、7 d、14 d and 30 d after the therapy.Results:The serum IL-6 and IL-10 levels in the patients with ACI were significantly higher than those in the healthy control group (P ＜ 0.05).The serum levels of IL-6 and IL-10 were correlated with the clinical impairment neurologic degree scores(P ＜0.05).The serum levels of IL-6 and IL-10 in patients of the safflower injection group were significantly lower than the patients of routine therapy group in 7 d and 14d.The neurologic function of the safflower injection group was better than that of the routine therapy group at 7 d、14 d、30 d after the therapy.Conclusions:The serum levels of IL-6 and IL-10 are significantly elevated in the patients with ACI.The serum levels of IL-6 and IL-10 are correlated with the volumes of infarction and the clinical neurologic impairment degree scores.the safflower injection may have certain neuroprotective effects in ACI patients.%目的:探讨急性脑梗死患者血清白细胞介素-6 (IL-6)、白细胞介素-10(1L-10)水平与神经功能缺损程度的相关性及红花注射液对其影响.方法:97例急性脑梗死患者采用酶联免疫法(ELISA)检测血清IL-6和IL-10水平,并与健康对照组比较,分析其临床神经功能缺损程度相关性.所有患者按照住院先后顺序随机分为常规治疗组(给予常规治疗)和红花注射液组(常规治疗基础上加红花注射液20 mL/d,连用14 d),治疗后24 h、7、14、30 d进行神经功能评分和血清IL-6、IL-10水平检测.结果:急性脑梗死患者血清IL-6和IL-10水平均明显高于健康对照组,并与临床神经功能缺损程度评分呈正相关.红花注射液组较常规治疗组在治疗后7、14 d血清IL-6、IL-10水平显著下降,神经功能缺损评分在治疗后7、14 d、30 d显著下降.结论:急性脑梗死患者血清IL-6、IL-10水平升高,与临床神经功能缺损程度密切相关,红花注射液有助于降低急性脑梗死患者血清IL-6、IL-10的水平,改善其神经功能.