铜绿假单胞菌中群体感应系统的研究进展

摘要

Quorum sensing is a kind of signaling pathway for communication among bacteria cells. Bacteria can monitor their population density and regulate hunderds of genes expression by detecting small diffusible molecules. The P. Aeruginosa quorum sensing circuitry is comprised of two complete systems (LasR/LasI and Rhll/RhlR) and one orphan 4-quinolone signalling system. This paper reviews the regulation mechanism and it's potential application of quorum sensing systems of P. Aeruginosa.%群体感应系统(quorum sensing)是一种细菌细胞与细胞间的信号传递系统.细菌通过可扩散的小分子信号分子感知细胞群体的密度,从而引起一些特定基因在细菌群体中的协调表达.铜绿假单胞菌中的QS系统包括LasI/LasR和RhlI/RhlR两条主要的信号系统和喹诺酮信号系统.本文系统地介绍了铜绿假单胞菌中QS系统的研究现状和相关应用.