噬菌体与抗菌剂联合应用研究进展

摘要

目前,细菌耐药性已成为危害公众健康的严重问题.噬菌体是地球上存在最丰富的生物,其作为细菌病毒具有裂解细菌的作用,许多动物模型试验及临床测试已经证明裂解性噬菌体有杀菌功效,噬菌体疗法的应用逐渐成为研究的必然选择.噬菌体虽然有希望成为抗生素替代品,但是越来越多的研究表明噬菌体与抗菌剂组合比二者单一使用能更有效地控制病原菌.本文就噬菌体与抗菌剂联合应用进行综述,主要讨论了噬菌体与抗生素、精油和细菌素等抗菌剂联合应用的研究进展.%Antibiotic-resistant bacterial infections are a major concern to public health.There is an urgent need to develop alternative therapies against bacterial pathogens and pests.However,one of the most promising is the employment of bacteriophage (phage),which is the most abundant viral entity of the planet.Phage therapy is now being re-evaluated as a means to treat or prevent bacterial infections worldwide,but an increasing number of studies suggest that the use of bacteriophage and antimicrobial agents in combination are more effective in controlling pathogenic bacteria than either alone.This article provided an overview of the combined application of bacteriophage and antimicrobial agents,and mainly discussed the research progress of phage combined with antibiotics,essential oils,bacteriocins and other antibacterial agents.