目的 研究男性少精子症及无精子症患者与染色体核型异常的关系.方法 对290例经精液常规检测,临床诊断为少精子症或无精子症的不育患者,抽取外周血进行淋巴细胞培养、G显带、核型分析.结果290例少精子症及无精子症患者的细胞遗传学分析中检出异常核型78例,其中性染色体异常68例,占全部被检者23.45％,占异常核型87.18％；常染色体异常10例占全部被检者21.38％,占异常核型12.82％.结论 染色体异常是造成男性少精子症及无精子症的重要因素,对临床上少精子及无精子患者进行染色体检查非常必要.%Objective To study the relationship between oligospermia and azoospermia patients and the abnormal chromosome karyotype. Methods Blood lymphocyte isolated from 290 oligospermia or azoospermia infertile patients was cultured, and G banding was stained and analyzed. Results 78 cases of abnormal karyotype were screened from 290 oligospermia and azoospermia patients. There were 68 cases of sex chromosome abnormalities, accounting for 23.45% of all the subjects, and 87.18% of the abnormal karyotypes. Besides, there were 10 cases of autosome abnormalities , about 21.38% of all the examiners and 12.82% of the chromosome abnormalities. Conclusion Chromosomal abnormality is the main reason for oligospermia and azoospermia. It is most important to make karyotype analysis of chromosome in oligospermia and azoospermia patients.
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