胎儿膀胱发育中肥大细胞量变的探讨

摘要

Objective: To study the variation of the mast cell number in human fetus in the course of the bladder deveolpment. Methods: The sectionsof bladder from 43 human fetuses at different gestation age were stained with Toluidine blue(TB) and Alcian blue-safranin(AB-S) mixutre respectively., then mast cell number was counted and analyzed statistically by analysis of variance. Results: In the fatuses at 3 months, a few mast cells began to be found and their number was 37.18 ±+ 5.72/mm2, whereasduring the 6th month, the number of mast cells increased greatly and was 161.48 + 4.38/mm2, beingabout 5 times of the primitive quantity, the varation was significant(P ＜ 0.01 ). Approach to delivery,the amount of mast cells reached 237.92 + 5.48/mm2, which was 7 to 9 times of the primitive.Conclusion: During bladder development of human fetus, the number of mast cells increases greatly as the fetus grows, especially before or after 6 months.%目的：探讨肥大细胞在人胎儿膀胱发育中的数量变化。材料和方法：43例不同胎龄的人胎儿膀胱切片做甲苯胺蓝(TB)和阿尔辛蓝-藏红(AB-S)染色并对肥大细胞进行计数和用方差分析做统计学处理。结果：胎儿膀胱肥大细胞3月龄时开始出现，数量为37.18±5.72个/mm2,6月龄时增长迅速，为161.48±4.38个/mm2，约是最初量的5倍，该变化具有统计学意义(P＜0.01)。9月龄时肥大细胞数量可达237.92±5.48％，约为最初量的7～9倍。结论：在人胎儿膀胱肥大细胞在6月龄前后明显增多，并且随着胎龄增长而进一步增多。