Objective: To explore the effect of gonadectomy-induced testosterone deprivation on growth, development and physiological structure of different organs and tissues. Methods: Male Kunming mice were selected and randomly divided into 3 groups: control, hemicastration and castration groups. All experimental mice were fed until 71 days of age under the same conditions and slaughtered to measure blood biochemistry indexes, carcass traits and viscera indexes, and histomorphology of different organs was analyzed. Results: Between hemicastration and control group, there was no significant difference in testis weight, level of serum testosterone, average daily gain and adult weight, which were significantly higher in control and hemicastration group than castration group. The heart weight, liver weight and kidney weight of castration group were significantly lower than control group, but spleen weight just was opposite, and lung weight had no significant difference in two groups. Conclusion: Testosterone deprivation induced by early gonadectomy exerts different effects on histomorphology of different tissues and organs in castration mice.%目的:研究睾酮缺失对雄性小鼠各脏器生长发育和生理结构的影响.方法:21日龄(断奶)雄性昆明小鼠随机分成对照组、单去势组和双去势组,在相同条件下饲养至71日龄(体成熟)处死并进行血液生化、屠体性状以及脏器指数的测量和计算,并对不同脏器组织进行组织形态学分析.结果:单去势组睾丸质量、睾酮含量、日均重、成年体质量与对照组均无显著差异,双去势组睾酮含量、日均重、成年体质量显著低于对照组和单去势组;双去势组心、肝、肾质量显著低于对照组,脾质量显著高于对照组,肺无显著差异.结论:早期去势诱导的睾酮缺失对小鼠各组织、器官组织形态学产生不同程度的影响.
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