复合型多糖类手性固定相的制备及其手性识别能力

摘要

将纤维素三(3,5-二甲基苯基氨基甲酸酯)(cellulose tris(3,5-dimethyIphenylcarbamate),CDMPC)和淀粉三(3,5-二甲基苯基氨基甲酸酯)(Amylose tris(3,5-dimethylphenylcarbamate),ADMPC)分别涂敷于氨丙基硅胶上然后混合,或者将这两种衍生物预先混合再涂敷,制备了两种复合型多糖类手性同定相.同时制备了基于CDMPC及ADMPC的单一型手性同定相,并进行了对比.研究表明:所制备的复合型手性固定相的手性识别能力一般介于两种单一型手性同定相的手性识别能力之间;少数对映体在复合型手性固定相上的分离变差;同时有一对对映体在复合型手性固定相上得到了更好的分离.%Two coated-type composite chiral stationary phases (CSPs) were prepared based on cellulose tris(3,5-dimethylphenylcarbamate) (CDMPC) and amylose tris (3,5-dimethylphenylcarbamate)(ADMPC) by coating the corresponding derivatives onto 3-aminopropyl silica gel separately and then mixing or by coating the mixed derivatives onto silica gel. The CSPs containing only CDMPC or ADMPC were also prepared for comparison. The mixing method does not significantly influence the enantioselectivities. The composite CSPs generally show chiral recognition abilities intermediate between those of the two individual phases, while some racemates were poorer and at the same time one was better resolved on the composite CSPs.