Objective To study the clinical characteristics of idiopathic hypoparathyroidism ( IHP ) and the related factors of main complications. Methods Clinical data of 44 hospitalized IHP cases from the first affiliated hospital of Guangxi medical university from December 1994 to September 2009 were retrospectively analyzed. Results The median duration was 30 months; misdiagnosis rate was 95. 5% ; 40 cases displayed limb tetany, seizures were seen in 19 cases, disturbance of intelligence was noted in 14 cases, cataract was noted in 6 cases; cerebral calcification was found in 26 cases. Cerebral calcification was among the risk factors of epilepsy ( B = 1. 168, OR =3. 216, P =0. 006 ); blood phosphate level was positively correlated with blood calcium x phosphorus product ( r = 0. 801, P = 0. 000 ); cerebral calcification was positively correlated with mental retardation and seizures ( r = 0. 408 , P=0. 01; r= 0.457, P =0.003). Conclusion Misdiagnosis rate and cerebral calcification rate are high among IHP patients; positive correlations exist between phosphate and blood calcium x phosphorus product, as well as cerebral calcification and mental retardation; cerebral calcification is among the risk factors of epilepsy.%目的 研究特发性甲状旁腺功能减退症(IHP)的临床特点及其主要并发症相关影响因素.方法 回顾性分析广西医科大学第一附属医院1994年12月-2009年9月确诊的44例IHP住院患者的临床资料.结果 中位病程为30个月;误诊率为95.5%;肢体搐搦40例,癫痫发作19例,智力障碍14例,白内障6例,脑钙化26例;脑钙化为癫痫发作的危险因素(B=1.168,OR=3.216,P=0.006);血磷与血钙磷乘积值为正相关关系(r=0.801,P=0.000);脑钙化与智力障碍及癫痫发作为正相关关系(r=0.408,P=0.010;r=0.457,P=0.003).结论 IHP误诊率、脑钙化发生率高;血磷与血钙磷乘积值、脑钙化与智力障碍呈正相关;脑钙化为癫痫发作的主要危险因素.
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