慢性阻塞性肺疾病稳定期血清肺表面活性蛋白D和C-反应蛋白与各因素之间的关系探讨

摘要

目的 观察血清肺表面活性蛋白D(SP-D)与C-反应蛋白(CRP)在慢性阻塞性肺疾病(COPD)稳定期的变化特点,探讨二者与各因素之间的关系.方法 选择COPD稳定期患者35例(COPD组)及健康体检者13例(对照组).抽取两组患者静脉血测定SP-D、CRP,行肺功能检测,收集体质指数、吸烟量及其他临床资料.对COPD组和对照组SP-D、CRP等进行比较,COPD组SP-D、CRP与体质指数、肺功能及其他因素进行相关分析.结果 COPD组的CRP和SP-D显著高于对照组,差异有统计学意义(P＜0.05),CRP与体质指数显著正相关(r=0.21),SP-D与1 s用力呼气量占预计值百分数(FEV1%预计值)显著负相关(r=-0.48).结论 在COPD病程中可能存在脂肪细胞诱导的全身炎症;SP-D可能是监测COPD严重程度的生物标记物.%Objective To investigate the concentrations of serum surfactant protein D ( SP - D ) and C - reaction protein ( CRP ) in the stable phase of chronic obstructive pulmonary disease ( COPD ) and the relationships between SP - D.CRP levels and COPD.Methods Thirty - five patients with COPD ( the COPD group ) and 13 health controls C the control group )were enrolled.Venous samples were obtained to detect CRP levels, SP - D levels, leukocyte counts and neutrophil percentage.Lung function was tested.Body mass index ( BMI ), cigarette smoking and other clinical data were collected.Clinical data from the COPD group were compared with those of the control group.Correlation analysis was performed among SP - D or CRP and BMI, lung function and other factors.Results SP - D and CRP levels of the COPD group were significantly higher than those of the control group.CRP level was positively correlated with BMI ( r =0.21 ), while SP - D was negatively correlated with FEV1 ％predicted ( r = -0.48 ).Conclusion Adipocyte - induced systemic inflammation might take place during COPD ; SP - D is of great importance as a biomarker for evaluating the severity of COPD.