Objective To research, by vitro and in vivo experiment, the impact of anti - inflammatory moisturizing lotion on staphylococcus aureus ( S.aureus ) of atopic dermatitis ( AD ).Methods Typical skin lesions of left ( or right ) upper ( or lower ) limbs were chosen as targets ( treatment group, washed by anti - inflammatory moisturizing lotion, 14 days ), contra-lateral lesions as control group ( given no treatment).After 14 days of treatment, S.aureus field planting density was compared between 2 groups.In vitro antibacterial activity of anti - inflammatory moisturizing lotion on standard S.aureus and methicillin resistant S.aureus ( MRSA ) was detected.Results S.aureus field planting density was significantly lower in treatment group [( 107 893 ± 260 049 ) CFU/cm2]than in control [( 343 321 ± 424 940 ) CFU/cm2]( P ＜ 0.05 ).Anti - inflammatory moisturizing lotion ( concentration: 1 g/ml) was of antimicrobial effect on standard S.aureus and MRSA, and there was significant difference between groups treatment and control ( 2％ sodium fusidate ) ( P ＜0.01 ).Conclusion Anti - inflammation and inhibition of S.aureus may be one of the main mechanisms of anti - inflammatory moisturizing lotion.%目的 通过体内外实验探讨润肤消炎洗剂对特应性皮炎(AD)皮损定植金黄色葡萄球菌(金葡菌)的影响.方法 选取23例AD患者,左侧(或右侧)上肢(或下肢)的典型皮损作为治疗组靶皮损,对侧相应皮损则作为对照组皮损.(1)治疗组靶皮损以润肤消炎洗剂外洗或湿敷,治疗14 d.对照组皮损不给予治疗.治疗14 d后比较两组皮损处金葡菌定植密度.(2)检测润肤消炎洗剂对标准金葡菌和耐甲氧西林金葡菌(MRSA)的体外抑菌活性.结果 (1)治疗后治疗组靶皮损的金葡菌定植密度[(107 893±260 049)CFU/cm2]显著低于对照组皮损[(343 321±424 940)CFU/cm2],差异有统计学意义(P＜0.05).(2)润肤消炎洗剂(中药浓度1 g/ml)对标准金葡菌和MRSA均具有抑菌作用,与阳性对照组(2%夫西地酸钠)的抑菌作用比较,差异有统计学意义(P＜0.01).结论 抗炎、抑制金葡菌可能是润肤消炎洗剂作用的主要机制之一.
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