Objective To evaluate the influence of ambroxol hydrochloride and clenbuterol hydrochloride on children cough variant asthma symptoms score and lung function.Methods 90 children with cough variant asthma ( CVA ) were randomly divided into group A, B and C, with each group 30 cases.Group A was given montelukast - na, group B was given montelukast - na combined with ambroxol hydrochloride and clenbuterol hydrochloride, and group C was given ambroxol hydrochloride and clenbuterol hydrochlorid.The changes of asthma control test score ( C - ACT ) and pulmonary function ( PEF mutation rate ) were observed in the three groups after treatment.Results After two weeks' treatment, the asthma control test score in group B was significantly higher than that in group A and group C ( P < 0.05 ), and the PEF mutation rate in group B was significantly lower than that in group A and group C ( P <0.05 ), but there's no significant difference between group A and group C in both the asthma control test score and the PEF mutation rate ( P >0.05 ).After four weeks' treatment, the asthma control test score and the PEF mutation rate in group A, group B and group C showed no statistically significant differences ( P >0.05 ).Conclusion Ambroxol hydrochloride and clenbuterol hydrochloride can significantly improve C - ACT score and lung function in children with CVA, and the combined use with montelukast - na has super-imposition effect.%目的 评价氨溴特罗联合孟鲁司特对儿童咳嗽变异性哮喘(CVA)的症状评分和肺功能的影响.方法将90例CVA患儿随机分为A、B、C 3组,每组30例.A组给予孟鲁司特治疗,B组给予孟鲁司特联合氨溴特罗治疗,C组给予氨溴特罗治疗.观察3组治疗后的哮喘控制测试评分(C-ACT)及肺功能(PEF变异率)的改变.结果 治疗后2周B组C-ACT评分明显高于A组和C组,差异均有统计学意义( P <0.05);A组和C组比较差异无统计学意义( P >0.05).治疗后4周C-ACT评分A、B、C 3组比较差异无统计学意义( P >0.05).治疗后2周PEF变异率B组明显低于A组和C组,差异均有统计学意义( P <0.05);A组和C组比较差异无统计学意义( P >0.05).治疗后4周PEF变异率A、B、C 3组比较差异无统计学意义( P >0.05).结论 氨溴特罗能显著改善CVA患儿的C-ACT评分和肺功能,与孟鲁司特联合使用,有叠加作用.
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