Synthesis of 1,1-Bis(hydroxymethyl)cyclopropane as Intermediate for Montelukast Sodium

摘要

1,1-Bis(hydroxymethyl)cyclopropane was synthesized by reaction dibromoneopentyl glycol with zinc powder at mole ratio of nDG:nzinc=1∶1.05 and 80°C (slightly reflux) for 7 hours.Under optimal conditions,yield and purity of the title compound were 87.3％ and 98.67％,respectively.Dibromoneopentyl glycol was also prepared in 91.7％ yield with pentaerythritol and hydrobromic acid as material and diethyl sulfate as catalyst under reflux for 10 hours.Structural characterization of 1,l-bis(hydroxymethyl)cyclopropane was conducted by IR and H-NMR.