目的 探讨非ST段抬高性心肌梗死和不稳定心绞痛(NSTEMI/UA)患者血浆脂肪激素Chemerin水平及其影响因素.方法 收集因胸痛住院并行冠状动脉造影的患者121例,根据患者的临床表现和冠状动脉造影结果分组:对照组44例、稳定冠心病组40例和NSTEMI/UA组37例.空腹抽血,测定血浆脂肪激素Chemerin水平及其他生化指标,如空腹血糖、血脂、肌酐、超敏C反应蛋白(hs-CRP)、白细胞、血浆纤维蛋白原等水平.结果 与对照组和稳定性冠心病组比较,NSTEMI/UA组血浆脂肪激素Chemerin水平升高[(229.45±25.47)ng/ml、(203.82±9.89)ng/ml和(214.53±12.24 ng/mL)ng/ml,P＜0.05].Pearson相关分析表明血浆脂肪激素Chemerin水平与入院时心率、白细胞总数、中性粒细胞、hs-CRP、纤维蛋白原、空腹血糖、肌酐呈正相关关系(r值分别为0.605、0.583、0.610、0.608、0.553、0.558和0.674,P＜0.001).结论 NSTEMI/UA患者血浆脂肪激素Chemerin水平明显升高,并与入院时心率、白细胞、中性粒细胞、hs-CRP、纤维蛋白原、空腹血糖和肌酐水平密切相关,提示Chemerin可能与不稳定斑块和继发血栓形成有关.%Objective To examine the plasma chemerin levels in patients with non - ST segment myocardial infarction/unstable angina ( NSTEMI/UA ) and its influencing factors. Methods The subjects were divided into three groups according to coronary angiography and the clinical presentation: control group ( n = 44 ), stable coronary heart disease group ( n = 40 ), and NSTEMI/UA group ( n = 37 ). Plasma chemerin level was detemined by ELISA; meanwhile, free blood glucose ( FBG ), blood lipids, cretinine ( Cr ), high - sensitivity C - reactive protein ( hs - CRP ), white blood cell ( WBC ), plasma fibrinogen and other factors were also analyzed. Results Compared with the control group and stable coronary heart disease group, NSTEMI/UA group has significantly higher plasma chemerin level [ ( 229. 45 ±25. 47 ) ng/ml, ( 203. 82 ±9. 89 ) ng/ ml, ( 214. 53 ± 12. 24 ) ng/ml, P <0. 05 ]. Pearson analysis demonstrated that plasma chemerin level was positively correlated with heart rate ( HR ), WBC, neutrophil, hs - CRP, fibrinogen, FBG, and Cr ( r = 0.605, 0.583, 0.610, 0.608, 0. 553, 0. 558 and 0. 674, P <0. 001 ). Conclusion Plasma chemerin level is significantly elevated in NSTEMI/UA patients and is correlated with HR, SBP, WBC, neutrophil, hs - CRP, fibrinogen, FBG, and Cr. Chemerin may be associated with atherosclerotic vulnerable plaque and play a role in thrombosis.Chemerin; Non ST segment elevated myocardial infarction; Unstable angina
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