乳腺癌基因组不稳定性的研究进展

摘要

乳腺癌是严重威胁世界女性健康的常见恶性肿瘤之一，近年研究发现，基因组不稳定性是肿瘤发生发展的重要分子机制，与肿瘤预后差及多重耐药相关。通过对乳腺癌相关基因改变的研究，寻找与乳腺癌发生相关的不稳定基因，探索其与乳腺癌发生发展的机制，是当前乳腺癌基因领域的一个重要研究方向，同时能够为个体化治疗提供新的靶点。本文主要就与乳腺癌基因组不稳定性相关的基因、形成机制以及临床应用方面的研究成果进行综述。%Breast cancer(BC)is one of the commonest malignancy threatening women's health in the world. Recent studies have showed that genomic stability is a major molecular mechanism in the occurrence and development of cancers,which is related to poor prognoses and multi - drug resistance. It is an important research orientation to find the unstable genes associat-ed with BC occurrence and to explore its mechanisms through the research on BC related gene changes,which can provide new targets for individualized treatments. This paper reviews the recent achievements in researches on genes related to BC genomic in-stability and its formation mechanism and clinical application.