健康青年仰卧位肺通气功能正常预计值研究

摘要

目的：初步建立河北地区健康青年仰卧位肺通气功能正常预计值公式，为仰卧位肺功能检测成为常规检查项目提供可靠依据。方法选取2012年3月-2013年9月在河北医科大学第四医院入职体检的健康青年248例，其中男性 BMI 18.5~<25.0 kg/ m2（正常）84例，≥25.0 kg/ m2（肥胖）14例；女性 BMI <18.5 kg/ m2（偏瘦）21例，正常120例，肥胖9例。采用耶格 MS 型功能仪测定受试者坐位和仰卧位肺通气功能指标，包括用力肺活量（FVC）、第1秒用力呼气末容积（FEV1）、FEV1/ FVC。采用多元逐步线性回归分析，分别以 FVC、FEV1、FEV1/ FVC为因变量，以年龄、身高、体质量为自变量，建立男、女仰卧位的肺通气功能预计值公式。结果体位比较显示，女性坐位 FVC、FEV1/ FVC 高于仰卧位（P <0.05）；女性 FEV1、男性 FVC、FEV1、FEV1/ FVC 坐位与仰卧位比较，差异均无统计学意义（P >0.05）。女性仰卧位 FVC、FEV1/ FVC 在不同体型间比较，差异均有统计学意义（P <0.05）；女性仰卧位 FEV1、男性仰卧位 FVC、FEV1、FEV1/ FVC 在不同体型间比较，差异均无统计学意义（P >0.05）。女性偏瘦仰卧位 FVC、FEV1预计值方程式比较，差异有统计学意义（P <0.05），正常体型男女性仰卧位 FVC、FEV1、FEV1/FVC 预计值方程式比较，差异有统计学意义（P <0.05）。结论在国内尚无仰卧位肺通气功能指标医学参考值的情况下，可以酌情参考此预计值方程式，有效评价仰卧位患者肺通气功能状况。%Objective To establish predicted equations for supine - position pulmonary function in healthy young peo-ple in Hebei Province,to provide a reliable reference for supine - position pulmonary function examination becoming a routine ex-amination. Methods In 248 healthy young people who had entry examinations in the Fourth Hospital of Hebei Medical Universi-ty from March 2012 to September 2013,there were 84 normal BMI males(BMI 18. 5 - < 25. 0 kg/ m2 ),14 obese(BMI≥25. 0 kg/ m2 ),and 21 thin females(BMI < 18. 5 kg/ m2 ),120 normal,9 obese. Using Jaeger MS - type functional instrument to determine the subjects' indexes of sitting - position and supine - position pulmonary function,including FVC,FEV1 ,FEV1 /FVC. Using stepwise multiple linear regression analysis,taking FVC,FEV1 ,FEV1 / FVC as dependent variables,and age, higher,body mass as independent variables,a predicted equation for males'and females' supine - position pulmonary function was established. Results The FVC,FEV1 / FVC of sitting position were higher than those of supine position in females(P <0. 05);there was no significant difference in females' FEV1 ,males' FVC,FEV1 ,FEV1 / FVC between sitting position and su-pine position(P > 0. 05). There was difference in FVC,FEV1 / FVC between different types of figure in females(P < 0. 05);there was no difference in females' FEV1 ,males' FVC,FEV1 ,FEV1 / FVC between different types of figure(P > 0. 05). The supine - position FVC,FEV1 predicted equations for thin females was significant(P < 0. 05),and those for males and females with normal types of figure was significant(P < 0. 05). Conclusion Since there are no domestic medical reference values for supine - position pulmonary function,using the above - mentioned predicted equations,which can evaluate supine - position pulmonary function effectively.