Objective To discuss the correlation between premature luteinizing hormone( LH)surge and ovulatory dysfunction in natural cycle for infertility women in the process of follicular development,and provide therapy basis for ART of nature cycle in infertility women. Methods 102 cases of infertility women were selected from the patients in Reproductive Center of Quzhou Maternal and Child Health - Care Center during the period from jan. 2010 to jan. 2012. Through the semi -quantitative urinary LH testing( uLH) combined with ultrasound,ovulate of 244 nature cycles in 102 infertility women, spontaneous LH surge value and fall surge time,follicular development were detected. This study divided the results into LH surge positive group,negative group and premature LH surge group. Ovulation rate,LUF rate and the pregnancy rate were compared among three groups. Results 138 cases,44 cases and 62 cases were divided into urinary LH surge positive group, negative group and premature LH surge group separately. Ovulation rate in 244 cycles was 77. 0%(118 cycles),the occurrence rate of LUF was 21. 3% (52 cycles),cycle pregnancy rate was 20. 9% (51 cycles). The ovulation rate,LUF rate,and pregnancy rate in three groups were 91. 3% , 63. 6% , 4. 8% ; 8. 7% , 31. 8% , 41. 9% ; 29. 0% , 11. 4% , 9. 7%respectively. The ovulation rate and cycle pregnancy rate in urinary LH surge positive group were higher than those in other two groups(P < 0. 05),while the occurrence rate of LUF was lower than that in other two groups( P < 0. 05). There was no difference between negative group and premature LH surge group(P > 0. 05). Conclusion Premature LH surge is easy to occur in the course of follicular development in natural cycle,which is the important factor of ovulatory dysfunction resulting low pregnancy rate in natural cycle. In clinical,the occurrence of premature LH surge can forecast the premature ovulate and the occurrence of LUFS. Injection of HCG in proper time and enhancing of luteal phase support can reduce the occurrence rate of LUF and improve the clinical pregnancy rate.%目的：探讨不孕症妇女自然周期卵泡发育过程中，过早内源性黄体生成素（LH）峰与排卵障碍的相关性，为不孕症妇女行自然周期的辅助生殖技术（ART）治疗提供依据。方法选择2010年1月—2012年1月衢州市妇幼保健院生殖中心不孕症门诊确诊的102例不孕症患者为研究对象，通过尿 LH 半定量检测试纸结合阴道超声，检测出102例不孕症妇女共244个自然周期的卵泡生长、内源性 LH 峰值及落峰时间、排卵情况，依据检测结果分为尿 LH 峰阳性组、尿 LH 峰阴性组及过早 LH 峰组，比较3组的排卵率、未破裂黄素化卵泡（LUF）发生率、周期妊娠率。结果尿 LH 峰阳性组138个，尿 LH 峰阴性组44个，过早 LH 峰组62个。244个自然周期总排卵率为77.0％（188个周期），LUF 发生率为21.3％（52个周期），周期妊娠率为20.9％（51个周期妊娠）。尿 LH 峰阳性组、尿 LH 峰阴性组及过早 LH 峰组的排卵率分别为91.3％、63.6％、54.8％，LUF 发生率分别为8.7％、31.8％、41.9％，周期妊娠率分别为29.0％、11.4％、9.7％；其中尿 LH 峰阳性组的排卵率、周期妊娠率均高于尿 LH 峰阴性组和过早 LH 峰组（P ＜0.05），尿 LH 峰阳性组 LUF 发生率低于尿 LH 峰阴性组和过早 LH 峰组（P ＜0.05），尿 LH 峰阴性组和过早 LH 峰组的排卵率、周期妊娠率、LUF 发生率比较，差异均无统计学意义（P ＞0.05）。结论自然周期卵泡发育过程中容易出现过早的内源性 LH 峰，是导致排卵障碍影响妊娠率的重要因素。临床实践中过早内源性 LH 峰的出现，可预测提早排卵及黄素化卵泡不破裂综合征（LUFS）的发生，可适时注射人绒毛膜促性腺激素，加强黄体支持，以降低 LUFS 的发生，提高临床妊娠率。
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