质子泵抑制剂与骨代谢关系的研究进展

摘要

质子泵抑制剂（PPI）被广泛应用于治疗胃食管反流病和消化性溃疡等酸相关性疾病，但有研究报道长期口服 PPI 可能会导致骨折风险增加。本文回顾了 PPI 与钙吸收、骨密度、骨折的关系，同时简述了其可能的发病机制。现有证据表明服用 PPI 与骨折风险增加具有一定的相关性，但关联性不强；PPI 导致骨折风险增加的机制尚未明确。所以，在临床实践过程中，需严格把握 PPI 治疗的适应证、疗程，尽量避免长期大量服用 PPI，尤其是骨折风险较高的患者。%Proton pump inhibitors(PPI)are widely used to treat acid - related disorders,such as gastroesophageal reflux disease and peptic ulcer. Studies have reported that the long - term use of PPI may lead to increased risk of bone fracture. This article briefly reviews the advances in the research about the relationship between PPI and calcium absorption,bone mineral density and bone fractures. The mechanism by which long - term use of PPI induces bone fracture is also reviewed. Current evidences show that there is a certain association between PPI therapy and the risk of fracture,but the correlation is not strong;the potential mechanism is still not clear. Therefore,in the clinical practice,indications and the course of treatment of PPI treatment should be strictly controlled,and the long - term administration of PPI should be avoided,especially for patients with high risk for bone fracture.